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2019, Stem Cells Australia, Tomorrow's Medicine Starts Today

Fixing hearts by finding out what makes them tick

You can learn a lot about hearts by trying to build one from scratch. A pair of scientists have grown ‘beating’ human heart muscle tissue from stem cells and are exploring cardiac regeneration.

Developmental biologist Associate Professor Enzo Porrello became interested in how newborn mammal hearts can regenerate while working in Dallas, Texas at one of the leading labs researching heart development.

Associate Professor James Hudson has a background in chemical and biological engineering. In Germany, he developed bioengineering techniques to make force-generating human heart tissue at the University Medical Center in Göttingen. Continue reading Fixing hearts by finding out what makes them tick →

2019, Stem Cells Australia, Tomorrow's Medicine Starts Today

Big data points the way to custom stem cells

Genomic biologist Professor Christine Wells and biostatistician Dr Kim-Anh Le Cao are analysing big data to discover what makes stem cells tick. Already the pair have found new ways to classify stem cells, and they’re working on predicting the cells’ behaviour and even creating custom immune cells.

Christine directs Stemformatics, an online encyclopaedia of hundreds of high-quality stem cell studies from other researchers vetted and archived by Christine’s team. They’ve amassed an enormous amount of data about genetic activity in certain stem cell types at many stages of development.

To find trends across the studies, Christine called on Kim-Anh’s statistical expertise. Continue reading Big data points the way to custom stem cells →

2019, Stem Cells Australia, Tomorrow's Medicine Starts Today

“Who will help me?”

People suffering from serious illnesses are turning to unproven and risky stem cell therapies in growing numbers. Researchers are trying to understand why—and how to provide better information and support.

Stem cells have been saving lives for decades, largely through bone marrow and cord blood transplants treating leukaemia and other blood diseases. Unproven treatments are booming, however, with clinics in Australia and around the world spruiking cures for conditions from osteoarthritis and MS to dementia and diabetes.

Associate Professor Megan Munsie and her colleagues in Stem Cells Australia’s Engagement, Ethics and Policy Program have heard many tales of patients spending thousands of dollars on treatments that often have no benefit and may be harmful or even deadly. Continue reading “Who will help me?” →

2019

What the universe is made of

The massive team that helped discover the Higgs boson is now hunting more exotic particles, including dark matter.

The ATLAS collaboration involves more than 3,000 physicists from around the world. In 2012, results from ATLAS were vital to the discovery of the Higgs boson, the particle that gives mass to everything in the Universe.

The 7000-tonne ATLAS detector at the Large Hadron Collider on the border of France and Switzerland tracks up to a billion collisions between high-energy protons each second. French and Australian physicists are at the forefront of efforts to decipher this torrent of data. Continue reading What the universe is made of →

2019, Stories of French-Australian Innovation

Peptides to fight pain

A new approach to the global chronic pain problem

Chronic pain affects around 20 per cent of the world’s population at any one time. It is the most common reason people seek medical help in Australia. Chronic pain often goes hand in hand with anxiety and depression.

Short chains of amino acids—known as peptides—may offer hope. A collaboration between neurobiologists at The Florey Institute of Neuroscience and Mental Health at The University of Melbourne and CNRS units affiliated with the Universities of Bordeaux and Strasbourg has made significant progress towards an entirely new approach to treating pain.

Continue reading Peptides to fight pain →

2019, Stories of French-Australian Innovation

The hunt for shapeshifting cancer cells

For a long time, doctors and patients have dreamed of precision oncology, a process that allows specific, effective treatments for individual tumours.

In the past, the complex nature of tumours has made this impossible.

“Within a tumour, there are many different cell populations, each doing different things and behaving in different ways. Most cells will be killed by chemotherapy, but some are not,” says Associate Professor Frederic Hollande of The University of Melbourne.

Continue reading The hunt for shapeshifting cancer cells →

2016, Australia-Indonesia Collaboration

Keeping ahead of a child killer: stopping gastro from birth

UPDATE 22 February 2018:  

A vaccine has been developed against rotavirus, which is the common cause  of severe diarrhoea and a killer of approximately 215,000 children under five globally each year.

The oral vaccine was given in three single doses, the first within five days of birth. After three doses of RV3-BB administered from birth:

  • 94 per cent of infants were protected in their first year of life against severe rotavirus gastroenteritis
  • 75 per cent of infants were protected to 18 months of age.

The success of the RV3-BB vaccine is the culmination of more than four decades of work, which started with the Murdoch Children’s Research Institute’s Professor Ruth Bishop and the discovery of rotavirus in 1973.

The trial was funded by the National Health and Medical Research Council (NHMRC), Bill & Melinda Gates Foundation and PT BioFarma.

Read the full media release on the MCRI website.

——

A new rotavirus vaccine should soon be available thanks to a collaboration between PT Bio Farma and researchers in Melbourne and Yogyakarta. The new ‘RV3’ vaccine is aimed at protecting babies from birth, improving protection and simplifying delivery.

The current vaccine, available in Australia and only on the private market in Indonesia, can only be administered from six weeks of age.

Continue reading Keeping ahead of a child killer: stopping gastro from birth →

2017

Radar-in-a-suitcase making bridges safer

Assessing ageing bridges just got safer and easier, thanks to a high-tech radar device that fits inside a suitcase.

Developed by Dr Lihai Zhang of The University of Melbourne as part of a collaborative research project supported by The Australia-Indonesia Centre, the IBIS-S radar technology can scan a bridge in 15 minutes from a kilometre away, quickly assessing its condition and stability.

Continue reading Radar-in-a-suitcase making bridges safer →

2017

Earthquake-proofing ports

Researchers from The University of Melbourne are learning how to modify existing Indonesian and Australian ports so earthquakes don’t do such devastating damage to sea trade.

“What we currently have is a recipe for disaster. Some of the port infrastructure is over 100 years old and wasn’t designed to cope with the loads they are currently bearing, let alone an earthquake,” says Dr Massoud Sofi.

Continue reading Earthquake-proofing ports →

2017

Gravitational waves—looking further

The brainpower of 18 institutions and more than $30 million are expanding the net to detect gravitational waves—disturbances in the fabric of spacetime—and cement Australia’s role in the emerging field.

Continue reading Gravitational waves—looking further →