You can learn a lot about hearts by trying to build one from scratch. A pair of scientists have grown ‘beating’ human heart muscle tissue from stem cells and are exploring cardiac regeneration.
Developmental biologist Associate Professor Enzo Porrello became interested in how newborn mammal hearts can regenerate while working in Dallas, Texas at one of the leading labs researching heart development.
Associate Professor James Hudson has a background in chemical and biological engineering. In Germany, he developed bioengineering techniques to make force-generating human heart tissue at the University Medical Center in Göttingen. Continue reading Fixing hearts by finding out what makes them tick
Examining how individual heart cells develop is revealing how the cells make decisions to form a working heart.
Once an adult heart is damaged, it has no ability to heal itself. Dr Nathan Palpant at the Institute for Molecular Bioscience at the University of Queensland and Associate Professor Joseph Powell at the Garvan Institute of Medical Research and the University of New South Wales are trying to understand how that might be changed by tracking individual stem cells along their journey to becoming heart cells.
“Heart development is a difficult and complicated process, but we think the answers to heart repair are likely to lie in understanding heart development,” Nathan says. “So we are using stem cells to model development as it occurs in our bodies.” Continue reading Studying heart development one cell at a time