Tag Archives: The Florey Institute of Neuroscience and Mental Health

Predicting change, brains, trains and mental health

State Awards

“Trait-based ecology” enables Macquarie University’s Mark Westoby to explain patterns of species occurrence and abundance and to understand the impacts of climate change and changing patterns of land use. He received the $55,000 NSW Scientist of the Year.

Nanocapsules for drugs delivery: Frank Caruso is making miniature capsules that could better deliver drugs for cancer, AIDS and cardiovascular diseases. He won one of the 2014 Victoria Prizes for Science & Innovation worth $50,000.

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The genetics of epilepsy: bringing hope to families

Sam Berkovic and Ingrid Scheffer have changed the way the world thinks about epilepsy, a debilitating condition that affects about 50 million people.

The Hon Tony Abbott, PM, with recipients of the 2014 Prizes, credit: Prime Minister’s Prizes for Science; Ingrid Scheffer and Sam Berkovic revealed the underlying genetic element of many epilepsies. Credit: Prime Minister’s Prizes for Science/WildBear
The Hon Tony Abbott, PM, with recipients of the 2014 Prizes, credit: Prime Minister’s Prizes for Science; Ingrid Scheffer and Sam Berkovic revealed the underlying genetic element
of many epilepsies. Credit: Prime Minister’s Prizes for Science/WildBear

Twenty years ago doctors tended to regard most forms of epilepsy as acquired rather than inherited. In other words, they believed epilepsy was mostly due to injury: the result of things like a crack on the head in a car accident, a bad fall in the playground, a tumour, or something having gone wrong in labour. Parents felt responsible and the resulting guilt was enormous.

The two clinician-researchers from The University of Melbourne have led the way in finding a genetic basis for many epilepsies, building on their discovery of the first ever link between a specific gene and a form of epilepsy. Finding that answer has been of profound importance for families.

Along the way, Sam and Ingrid discovered that a particularly severe form of epilepsy, thought to result from vaccination, was actually caused by a gene mutation. This finding dispelled significant concerns about immunisation.

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