Stem cells are being used to rapidly test and improve treatments for cataracts, thanks to an innovative solution developed by Dr Michael O’Connor and his team from Western Sydney University.
With novel stem cell technology, Michael has created hundreds of thousands of micro-lenses similar to the ones in the human eye. These micro-lenses offer a way to rapidly improve drug research and offer the potential for lens cell transplants in the future.
Billions of dollars are spent each year around the world on cataract surgery, and hundreds of millions of dollars treating resulting complications. Continue reading Micro-lenses bring new cataract treatments in sight
For the past decade scientists have been able to reprogram skin cells, nasal cells and other mature cells to become pluripotent stem cells that can turn into any cell type in the human body. How it works is only starting to become clear.
Teams led by Professors Ryan Lister at the University of Western Australia, Jose Polo at Monash University and Ernst Wolvetang at The University of Queensland are working together to understand how this process occurs, whether all cell types follow the same path to becoming pluripotent cells, and if this impacts their ability to mimic disease in the laboratory.
Through a series of collaborations over the last ten years the scientists have uncovered a number of stem cell secrets, opening the door for more targeted research and, ultimately, treatments for diseases. Continue reading How reprogramming cells turns back time
Professor James Bourne and his team are laying the groundwork for using stem cell transplants to treat brain trauma with the discovery of an anti-scarring agent and new biomaterials to support transplanted cells.
“What we’re doing is a prelude to direct stem cell research. We hope to give potential stem cell therapies for brain trauma the best chance of success,” James says.
He and his team at the Australian Regenerative Medicine Institute at Monash University are studying nonhuman primates to understand how to create the best environments for repair after brain injury. Continue reading Building tools for brain repair
People suffering from serious illnesses are turning to unproven and risky stem cell therapies in growing numbers. Researchers are trying to understand why—and how to provide better information and support.
Stem cells have been saving lives for decades, largely through bone marrow and cord blood transplants treating leukaemia and other blood diseases. Unproven treatments are booming, however, with clinics in Australia and around the world spruiking cures for conditions from osteoarthritis and MS to dementia and diabetes.
Associate Professor Megan Munsie and her colleagues in Stem Cells Australia’s Engagement, Ethics and Policy Program have heard many tales of patients spending thousands of dollars on treatments that often have no benefit and may be harmful or even deadly. Continue reading “Who will help me?”
Gene editing technology combined with stem cells provides a powerful new way to study genetic kidney diseases and their treatments.
Melbourne researchers have used mini-kidney ‘organoids’ grown in the lab to unravel the mystery of why Mainzer-Saldino syndrome, a rare disease involving a single defective gene, causes life-threatening kidney damage. In doing so, they’ve proven an approach that can be used to study a whole range of other genetic kidney diseases. Continue reading Mini-kidneys tell two sides of a genetic story
Australians have some of the highest rates of unhealthy habits in the world, including excessive eating, drinking, gambling, and recreational drug use. These habits are making us stressed and unhappy, and contributing to poor physical and mental health.
Breaking a habit is hard. Beating major compulsive problems, like addictions or obsessive-compulsive disorder (OCD), is even harder. Eighty per cent of people who need help don’t get it, and 80 per cent of those who do seek help relapse within a year.
“Our current solutions aren’t good enough: many are difficult to access, many are ineffective. And there’s a huge amount of stigma attached,” says Dr Rebecca Segrave, Deputy Director of Monash University’s new BrainPark facility.
At BrainPark, world-leading scientists and health professionals are combining new technologies and lifestyle-based treatments to empower people to change their own brains and create healthy habits.
Continue reading BrainPark will reveal the science of beating addiction
An electronic astronaut is helping researchers spot the difference between normal four-year-old energy and the signs of attention difficulties.
TALI (Training Attention and Learning Initiative) Detect is a series of short games for tablet computers. It’s been made possible by combining 20 years of neuroscientific research at Monash Institute of Cognitive and Clinical Neurosciences (MICCN) with the expertise of Australian game developer Torus Games.
Continue reading A different kind of tablet to test for early childhood attention difficulties
Being a teenager is tough—on teenagers and their parents. While there’s lots of advice on the internet, sorting the credible from the questionable can be difficult.
But hundreds of parents around Australia found that accessing a free, online support program improved their parenting skills and confidence, according to two randomised controlled studies from 2015 to 2017.
The program, called Partners in Parenting (PiP), was developed by experts at Monash University and The University of Melbourne.
Continue reading An expert guide to raising teens
A new approach to the global chronic pain problem
Chronic pain affects around 20 per cent of the world’s population at any one time. It is the most common reason people seek medical help in Australia. Chronic pain often goes hand in hand with anxiety and depression.
Short chains of amino acids—known as peptides—may offer hope. A collaboration between neurobiologists at The Florey Institute of Neuroscience and Mental Health at The University of Melbourne and CNRS units affiliated with the Universities of Bordeaux and Strasbourg has made significant progress towards an entirely new approach to treating pain.
Continue reading Peptides to fight pain
“We make bacteria do amazing things.”
Researchers at the University of Adelaide and the Pasteur Institute in France are creating biological factories within cells to make and detect molecules for a wide range of uses in health, environmental monitoring and industry.
Synthetic biology—the application of engineering principles to build new biological parts, circuits and devices—has been used to build tumour-killing bacteria, for example, and has great potential for green chemistry that uses fermentation rather than petrochemicals.
Continue reading Creating living cell factories