All posts by Michael Lucy

How much carbon can we dig in?

Healthy soil for a healthy planet

To rein in global warming, scientists believe it will not be enough to reduce our greenhouse gas emissions: we will also need to remove CO2 from the atmosphere.

Soils are an important reservoir for carbon, as they contain nearly double that found in the atmosphere and vegetation combined. Agricultural practices have degraded soil carbon stocks, so there is a large potential for atmospheric carbon to be sequestered in soils.

Continue reading How much carbon can we dig in?

Spying on the denizens of the Southern Ocean

Sonar and satellites reveal the fish and other creatures that live far below the surface.

The depths of the ocean still hold great mysteries. At depths between 200 and 1,000 metres live creatures that, taken altogether, weigh as much as 10 billion tonnes.

Rudy Kloser, an expert on echo sounding and deep-sea ecosystems at CSIRO in Hobart, says these creatures are vital but poorly understood. Continue reading Spying on the denizens of the Southern Ocean

Big data for life

Australian and European researchers are finding the secrets of cancer and the immune system hiding in the numbers.

From his lab at the South Australian Health and Medical Research Institute (SAHMRI), Irish-born researcher David Lynn is combining computational and big data analysis with experimental approaches to unpicking biological networks at the molecular level. Continue reading Big data for life

Australian mirrors helping to power Cyprus

Australian-made mirrors are helping the Mediterranean country of Cyprus move to renewable energy and secure its supply of drinking water.

Though Cyprus is blessed with plentiful sunshine, rainfall is low and the country depends on energy-intensive desalination plants for its drinking water. Continue reading Australian mirrors helping to power Cyprus

Fixing hearts by finding out what makes them tick

You can learn a lot about hearts by trying to build one from scratch. A pair of scientists have grown ‘beating’ human heart muscle tissue from stem cells and are exploring cardiac regeneration.

Developmental biologist Associate Professor Enzo Porrello became interested in how newborn mammal hearts can regenerate while working in Dallas, Texas at one of the leading labs researching heart development.

Associate Professor James Hudson has a background in chemical and biological engineering. In Germany, he developed bioengineering techniques to make force-generating human heart tissue at the University Medical Center in Göttingen. Continue reading Fixing hearts by finding out what makes them tick

Modelling brain circuitry

With the help of a revolutionary robot, Professor David Adams and Associate Professor Mirella Dottori are studying neurons, testing drug candidates for chronic pain, and working towards precise, personalised neurological treatment.

David has been studying the neurology of chronic pain, while Mirella is a neural stem cell expert. Based at the University of Wollongong, their collaboration focusses on cells called dorsal root ganglia sensory neurons. These cells sense pressure, temperature, position, touch and pain, and the duo believe they could hold the key to many neurological disorders including chronic pain.

“Many diseases and disorders are caused by altered firing of signals along sensory nerves. Growing human sensory neurons [from stem cells] means we can study their development and function in both health and disease,” says Mirella. Continue reading Modelling brain circuitry

Studying heart development one cell at a time

Examining how individual heart cells develop is revealing how the cells make decisions to form a working heart.

Once an adult heart is damaged, it has no ability to heal itself. Dr Nathan Palpant at the Institute for Molecular Bioscience at the University of Queensland and Associate Professor Joseph Powell at the Garvan Institute of Medical Research and the University of New South Wales are trying to understand how that might be changed by tracking individual stem cells along their journey to becoming heart cells.

“Heart development is a difficult and complicated process, but we think the answers to heart repair are likely to lie in understanding heart development,” Nathan says. “So we are using stem cells to model development as it occurs in our bodies.” Continue reading Studying heart development one cell at a time

Big data points the way to custom stem cells

Genomic biologist Professor Christine Wells and biostatistician Dr Kim-Anh Le Cao are analysing big data to discover what makes stem cells tick. Already the pair have found new ways to classify stem cells, and they’re working on predicting the cells’ behaviour and even creating custom immune cells.

Christine directs Stemformatics, an online encyclopaedia of hundreds of high-quality stem cell studies from other researchers vetted and archived by Christine’s team. They’ve amassed an enormous amount of data about genetic activity in certain stem cell types at many stages of development.

To find trends across the studies, Christine called on Kim-Anh’s statistical expertise. Continue reading Big data points the way to custom stem cells

Clearing corneas and restoring vision

The eye’s cornea depends on stem cells to help maintain transparency. If disease or trauma deplete stem cell reservoirs, a rapid and painful loss of vision soon follows.

Professor Stephanie Watson and Professor Nick Di Girolamo have used stem cells to repair their patients’ vision. It’s the culmination of a 15-year collaboration to restore sight in Australians with corneal disease.

Stephanie is an international leader in research and innovation with the University of Sydney and is also a practising corneal surgeon. She met Nick as an early career scientist through a research group at the University of New South Wales and they discovered their shared interest. Nick is now a Director with the School of Medical Sciences at UNSW. Continue reading Clearing corneas and restoring vision

Enlisting the brain’s immune cells to fight MS

The brain’s specialist cleaning cells play a key role in neurodegenerative diseases, and they may also hold the secret to new treatments for the likes of MS and Alzheimer’s.

Professor Colin Pouton and his team at the Monash Institute of Pharmaceutical Sciences found a way to isolate microglia, the immune cells of the brain, from stem cells. Better yet, they made the cells fluorescent so their activity can be tracked, opening up new avenues of research.

Professor Trevor Kilpatrick and his colleagues at the Florey Institute of Neuroscience and Mental Health think Colin’s engineered cells just might be the key to creating a revolutionary treatment for multiple sclerosis. Continue reading Enlisting the brain’s immune cells to fight MS