The secrets of a molecular assassin could lead to more effective treatments for cancer and viral diseases, better therapy for autoimmune conditions, and a deeper understanding of the body’s defences enabling the development of more tightly focused immunosuppressive drugs.
In this simulation, the perforin molecule (blue) punches a hole through the cell membrane (beige) providing access for toxic enzymes (red). Credit: Mike KuiperThese are just some of the wide-ranging possibilities arising from research which has revealed the structure and function of the protein perforin, a front-line weapon in the body’s fight against rogue cells.
A pivotal role was played by 2006 Science Minister’s Life Scientist of the Year, molecular biologist Prof James Whisstock and his research team at Monash University. It was research fellow Dr Ruby Law who finally worked out how to grow crystals of perforin. And the team was then able to collaborate with Dr Tom Caradoc-Davies of the micro-crystallography beamline at the nearby Australian Synchrotron to reveal its complete molecular structure. Continue reading How a molecular assassin operates→
The world’s meat production could be lifted by 10 to 15 per cent if a vaccine can be found to combat the liver fluke.
Juvenile liver fluke parasites which cause serious disease in livestock and humans. Credit: D Piedrafita (Monash); T Spithill (La Trobe).This is the aim of a collaborative bioscience group at the new $288 million Centre for AgriBioscience (AgriBio).
An effective vaccine against liver fluke could not only boost meat production but would also lead to a large reduction in the amount of drugs given to livestock, says Prof Terry Spithill, who is co-director of AgriBio and based at La Trobe University. Continue reading Stopping parasite means more, safer meat→
Each year we identify early-career scientists with a discovery and bring them to Melbourne for a communication boot camp. Here are some of their stories.
Jacek Jasieniak sprinkling quantum dots. Credit: Jacek Jasieniak
Imagine printing your own room lighting, lasers, or solar cells from inks you buy at the local newsagent. Jacek Jasieniak and colleagues at CSIRO, the University of Melbourne and the University of Padua in Italy, have developed liquid inks based on quantum dots that can be used to print such devices and in the first demonstration of their technology have produced tiny lasers. Quantum dots are made of semiconductor material grown as nanometre-sized crystals, around a millionth of a millimetre in diameter. The laser colour they produce can be selectively tuned by varying their size.
Colin Scholes operates a test rig for his carbon capture membrane. Credit: CO2 CRC
High tech cling wraps that ‘sieve out’ carbon dioxide from waste gases can help save the world, says Melbourne University chemical engineer, Colin Scholes who developed the technology. The membranes can be fitted to existing chimneys where they capture CO2 for removal and storage. Not only are the new membranes efficient, they are also relatively cheap to produce. They are already being tested on brown coal power stations in Victoria’s La Trobe Valley, Colin says. “We are hoping these membranes will cut emissions from power stations by up to 90 per cent.”
VESKI’s main initiative – to return successful Australian expatriates with outstanding skills in science, technology and design – is paying off with some inspiring work.
In 2004, VESKI’s – Victorian Endowment for Science, Knowledge and Innovation – inaugural Fellow Professor Andrew Holmes returned from Cambridge University to work in a new $100 million Bio21 Molecular Biology and Biotechnology Institute. One of the most important research areas to emerge since has been the development of cheap plastic solar cells.
Embryonic stem cells from cattle can now be stored in mass in the laboratory, paving the way for advanced breeding developments in dairy cattle and other livestock.
These new ways of efficiently isolating and maintaining cells provide scientists from Australia’s Dairy Cooperative Research Centre with the raw materials to investigate a range of stem cell applications.
Staff in a Monash University-led project, called Water Sensitive Cities, believe the time is right for a bold idea that could produce 20 to 30 per cent of Melbourne’s future water needs.
Annually, almost as much stormwater falls on Melbourne as its citizens use, but only a fraction is captured and reused. Billions of litres of stormwater literally go down the drain and into Port Phillip Bay, degrading the ecological health of Melbourne streams and the bay.
Womb stem cells could help regenerate a diseased liver.
What if the very thing that assists a fetus to grow in the womb could also prevent disease in a fully grown adult?
Monash Institute of Medical Research scientists have discovered that stem cells from the womb have the potential to treat inflammatory diseases such as lung fibrosis and liver cirrhosis in both children and adults.
Michael Cowley has shown how our brain tells our body we are full. Credit: Department of Innovation, Industry, Science and Research
Why do we get fat? What’s the link between obesity, diabetes and hypertension? Can we break the link? These are critical questions around the world. Prof. Michael Cowley may have the answers.
He’s shown how our brains manage our consumption and storage of fat and sugar and how that can go wrong. He’s created a biotech company that’s trialling four obesity treatments.
Why does influenza make some of us much sicker than others? What are the implications for swine flu (H1N1)? Australian scientists are looking to past outbreaks for the answers.
In July 2009, the Australian Government responded to urgent global calls to use the Southern Hemisphere’s flu season as a catalyst for investigating the severity and global threat of the H1N1 flu strain.
As a child, Natalie Borg tried to grow crystals. Two decades on, she is still growing crystals. But now she is analysing them with synchrotron light, to figure out how our bodies mount a rapid defence when we are attacked by viruses.
Natalie Borg at work in the lab. Photo credit: L’Oréal/SDP Photo
“The immune system is complex and is made up of many specialised types of cells and proteins. The key is to understand their function,” Natalie says.
To date, she’s been working as part of a successful team at Monash University. In 2007 her work on how our natural killer T cells recognise fats from invaders was published in Nature.
Now she’s setting up her own laboratory at Monash—a bold move but essential if her career is to grow. With the help of her L’Oréal Australia For Women in Science Fellowship, she will study key steps in our body’s early warning system against viral attack.
