A new diagnostic system used to detect cancer cells in small blood samples could next be turned towards filtering a patient’s entire system to remove those dangerous cells – like a dialysis machine for cancer – says an Australian researcher who helped develop the system.
The technique was developed for cancer diagnosis, and is capable of detecting (and removing) a tiny handful of cancer-spreading cells from amongst the billions of healthy cells in a small blood sample.
The revolutionary system, which works to diagnose cancer at a tenth of the cost of competing technologies, is now in clinical trials in the US, UK, Singapore and Australia, and is in the process of being commercialised by Clearbridge BioMedics PteLtd in Singapore.
The possibility of a link between vitamin D deficiency and pneumonia is being investigated in two studies by Indonesian and Australian scientists in Indonesia.
They’re tracking the incidence and severity in early childhood of respiratory tract infections, including the common cold, asthma, pneumonia, and bronchiolitis, in hospitals and the community, in the hope of providing more information for treatment and management for respiratory diseases.
A mother and her newborn with a midwife, after cord blood has been collected. Credit: Mr Noor Qodri H
Pneumonia is the number one killer of children under five in the country, and around six million young Indonesians suffer from it each year, according to a 2008 study. This collaboration is going to update those 2008 figures, and hopefully lower them – while trying to find the causes of it and other respiratory tract infections. Continue reading Can sunshine help prevent pneumonia?→
“You can’t teach anatomy without bodies. Or at least you couldn’t until now,” says Monash University’s Paul McMenamin.
He and his colleagues are printing 3D plastic body parts of unprecedented detail and accuracy that have the potential to revolutionise anatomy teaching.
The printed parts will hold up to repeated handling and close study. Credit: Centre for Human Anatomy Education
Anatomy students need a high degree of familiarity with the intricate details of the human body. That ideally comes with repeated handling and hands-on study. But students are often reluctant to touch a cadaver any more than necessary.
Removing the emotional, ethical and physical restrictions to close handling and repeated study improves the students’ familiarity with the human body. Another advantage of the printing is the expertly applied false colouring picking out intricate nerves, veins, arteries and ligaments that are much harder to identify in preserved cadavers.
Only 10 per cent of prostate cancers are lethal, but which ones? Australian researchers have tracked the mutations that drive the cancer to spread through the body, and eventually become lethal.
Bioinformaticians can use Circos plots to visualise how cancer genomes differ from healthy ones. Credit: Peter Casamento
The research shows they can be detected in the original tumour and even in blood samples. Testing the DNA of prostate cancer cells may help clinicians in the future identify which cancers need to be urgently removed and which ones might simply be monitored.
“Some advanced cancer cells evolve the ability to break away from their original location, travel through the bloodstream and create secondary tumours in another part of the body,” explains Clare Sloggett, Bioinformatician and Research Fellow at the Victorian Life Sciences Computation Initiative (VLSCI). “Cells in this state of metastasis are the most deadly.”
Footy player, netballer and ballet dancer available for interview
Re-training the brain with painless exercises may be the key to stopping recurring tendon pain, according to Melbourne researchers.
Dr Ebonie Rio
AFL, basketball and netball players are the major sufferers, with tendon pain in the knee debilitating and long-lasting. The injury can sideline a player or cause them to give up the sport entirely.
“More than 50 per cent of people who stop sport because of tendon pain still suffer from that pain 15 years later,” says Dr Ebonie Rio of the Monash University Tendon Research group.
“Our simple exercise is revolutionising how we treat tendinopathy.”
Pain relief during childbirth may soon be delivered via a self-administered nasal spray, thanks to research from University of South Australia midwifery researcher, Dr Julie Fleet.
Well known for its use in delivering pain relief to children and in managing pain in patients being transferred by ambulance, the nasal spray analgesic drug, fentanyl, has now been shown to be effective in relieving labour pain.
Julie Fleet, University of South Australia
In fact Julie and her colleagues at Flinders University and the University of Adelaide have found that fentanyl nose spray is just as effective as pethidine injections, which are commonly used, but fentanyl has fewer side effects for both mother and baby.
Relief isn’t a term commonly associated with spiders, but Glenn King has found promising molecules in tarantula venom that he hopes will bring respite to the one in five Australian adults suffering from chronic pain.
Dr Muireann Irish, cognitive neuroscientist, Neuroscience Research Australia/UNSW, Sydney
Dr Muireann Irish has discovered which parts of our brain are essential to imagine the future, ranging from simple things like “I must remember my keys and my wallet when I go out,” to imagining complex events such as “my next holiday”. And she has shown that people with dementia don’t just lose the ability to remember the past, they also lose the ability to envisage the future.
She will use her L’Oréal-UNESCO For Women in Science Fellowship to better understand how dementia affects this cognitive function. She expects her work will inform the development of activities for patients that will improve their quality of life and reduce the burden faced by caregivers.
Cognitive decline in the form of dementia will be one of the greatest challenges for our health system in the next fifty years and Muireann is leading the search for solutions.
To read about Japan-Australia innovation collaborations—including searching for new malaria drugs, giant robot trucks carrying ore, and chewing gum that reverses tooth decay—click here.
Japanese science changing Australia
The impact of Japanese technological prowess on Australian society is obvious for all to see. How we listened to music was transformed by audio recording technologies: from the Walkman to the CD. Home entertainment was changed by video tapes, DVDs, and game consoles. We rely on Japanese innovation in transport—reliable car engineering, the lean manufacturing techniques that made them affordable and, more recently, hybrid cars.
Fundamental science discoveries are bringing a new era of transformation. Japanese researchers were honoured last year with the Nobel Prize for their invention of the blue LED. They succeeded where for 30 years everyone else had failed. Incandescent light bulbs lit the 20th century; the 21st century will be lit by LED lamps—lasting a lifetime and using a fraction of the energy.
In 2006 Shinya Yamanaka discovered how intact mature cells in mice could be reprogrammed to become immature stem cells. By introducing only a few genes, he could reprogram mature cells to become pluripotent stem cells, that is, immature cells that are able to develop into all types of cells in the body. His work is transforming stem cell medicine and many Australian researchers are now using induced pluripotent stem cells to develop stem cell medicines.
IVF, heart research, and coral research gain from working together
Australian and Japanese science leaders understand the importance of internationalising their research—creating international science networks that are more than the sum of their parts. And the complementary strengths of the two countries result in greatly enhanced research when they work together.
President of The Systems Biology Institute Hiroakai Kitano with CEO of Monash IVF James Thiedeman (left), credit: EMBL Australia
Science is becoming increasingly multidisciplinary, and the collaborations between Japan and Australia reflect this trend. One rapidly growing network is being driven by the Systems Biology Institute of Japan, together with Monash University and the Australian affiliate of the European Molecular Biology Laboratory (EMBL). The natural partners joined forces in 2013 to create SBI Australia, the Japanese Institute’s first international affiliate. It was joined by SBI Singapore in 2014. Continue reading Internationalising science together→
Hundreds of Aussie science achievements that you can share in speeches, posts and publications
