Expanding treatments for the ‘Australian’ cancer

The chances of surviving melanoma are getting better every year. But some cancers still become ‘resistant’ to treatment, and others don’t respond at all.

Helen and her colleagues are searching for clues on how people will respond to treatment. Credit: Carolyn Seri for Melanoma Institute Australia Report
Helen and her colleagues are searching for clues on how people will respond to treatment. Credit: Carolyn Seri for Melanoma Institute Australia Report

A collection of over 10,000 blood and 4,900 tissue samples from the biobank at the Melanoma Institute Australia is being used to hunt for clues to predict which patients won’t be responsive to treatment from day one. The researchers, from Macquarie University, are also looking for the basis of developed resistance by the cancer.

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Tracking dust

Statisticians have revealed the surprising source of dust that plagues townships beside a Hunter Valley rail line delivering coal to Newcastle’s busy port.

Airborne dust increases as trains pass. But it wasn’t clear exactly how—for example, whether the dust was escaping uncovered coal wagons or coming from the diesel engines pulling the wagons. The answer was surprising.

Mathematicians from the ARC Centre of Excellence for Mathematical and Statistical Frontiers correlated air-pollution data against information on passing trains and weather conditions.

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Fishing for food security

Local fishermen in Indonesia are catching less fish. Whatever the reason, it is a significant problem for those who live on small islands in particular, as fish make up about 90 per cent of the protein they eat.

A team of Indonesian and Australian social scientists is looking at how communities adapt to these changes.

Initially, in a pilot project study financed by the Australia Indonesia Centre, the researchers are examining whether there is a link between fishing productivity and feelings of food insecurity in the small islands off Kai Kecil, and if so, whether a weakening of local management of fish populations and a rise in intercommunity conflicts over fish resources play a role.

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Widening the net on Motor Neurone Disease

Recent advances pinpointing genes involved in the inherited form of Motor Neurone Disease (MND) are now being used to hunt for the culprits of ‘sporadic’ cases.

Ian and his team are hunting the genes involved in Motor Neurone Disease. Credit: Paul Wright
Ian and his team are hunting the genes involved in Motor Neurone Disease.
Credit: Paul Wright

Sporadic MND is the most common form (around 90 per cent), and unlike the ‘familial,’ disease, it appears in patients without a family history.

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Build it and they will come – chip design creates computer blueprint

The design of a 3D silicon chip architecture clears another hurdle in the international race to build quantum computers.

Researchers at the University of Melbourne and the University of New South Wales (UNSW) have designed a chip based on single atom quantum bits, creating a blueprint for building a large-scale silicon quantum computer.

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Feeding the world, and asking where the wind went

Life on land depends on plants. And every plant balances opening its pores to let in carbon dioxide for photosynthesis; and closing its pores to retain water.

Graham Farquhar’s work has transformed our understanding of photosynthesis.

His models of plant biophysics have been used to understand cells, whole plants, whole forests, and to create new water-efficient wheat varieties.

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Making jet engines (and power generation) more efficient

It’s very hard to set up a jet engine in a wind tunnel and get accurate measurements inside it while it’s rotating 7,000 times a minute.

As air passes over these turbine blades (flowing from right to left) a wake is created which interacts with the next (lower) blade. Credit: Richard Sandberg and Richard Pichler
As air passes over these turbine blades (flowing from right to left) a wake is created which interacts with the next (lower) blade.
Credit: Richard Sandberg and Richard Pichler

So while other members of the University of Melbourne’s mechanical engineering department use wind tunnels to measure turbulence on the surface of airplanes, Professor Richard Sandberg has developed a computer program to make the same measurements inside an engine.

His work also applies to the turbines used to generate power from gas, wind and wave.

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The water beneath our feet

Subterranean caves in the Blue Mountains have been

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Measuring infiltration water in the Wombeyan Caves, New South Wales. Credit: Andrew Baker

converted into observatories to quantify how water moves through buried rock structures into groundwater.

Groundwater forms the world’s largest active repository of fresh water—more than a hundred times larger than rivers and lakes combined.

To use that groundwater resource sustainably, we need to know that we are only using as much water as is being continually replaced, mostly via rainfall and underground leakage from rivers.

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Helping patients cope with cancer

Pairing psychology with cancer treatment has a profound impact on the wellbeing of patients, Associate Professor Maria Kangas and her team at the Centre for Emotional Health have found.

CBT helps give patients the skills to cope with the challenges of cancer diagnosis. Credit: Chris Stacey
CBT helps give patients the skills to cope with the challenges of cancer diagnosis. Credit: Chris Stacey

In a recent clinical trial, head and neck cancer patients were offered weekly cognitive behavioural therapy (CBT) sessions concurrent to their radiation therapy appointments.

After just seven sessions, patients reported a significant decline in cancer-related anxiety and/or depression. And after a year, 67 per cent were no longer experiencing any anxiety or depression and were doing better than the control group who had received regular counselling, but not CBT.

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Printing a cartilage repair kit

A new printing technology can now simultaneously print living stem cells and the environment they need to survive and become the right cell type. The first application is a cartilage repair kit.

“Our current 3D printers can integrate living and non-living materials in specific arrangements at a range of scales, from micrometres to millimetres,” says Professor Gordon Wallace, Director of the ARC Centre of Excellence for Electromaterials Science (ACES) at the University of Wollongong.

“And we’re developing new approaches that will enable 3D printing of nano-dimensional features.”

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