The complex life of coral

Tracy Ainsworth

James Cook University
Coral interactions more complex than ever suspected.

Tracy Ainsworth, James Cook University (credit: L’Oréal Australia/sdpmedia.com.au)
Tracy Ainsworth, James Cook University (credit: L’Oréal Australia/sdpmedia.com.au)

Dr Tracy Ainsworth’s research is changing our understanding of the life of the tiny coral animals that built Australia’s iconic Great Barrier Reef.

Her work comes at a critical time for the future of coral reefs—threatened by a warming ocean and by coral bleaching. Continue reading The complex life of coral

Silicon solves helicopter corrosion

An inexpensive, environmentally friendly alternative to a toxic coating currently used in Australian naval helicopters has been developed at Monash University in collaboration with CAST Cooperative Research Centre in Melbourne.

A non-toxic coating will reduce environmental and maintenance costs in Seahawk helicopters. Credit: US Navy
A non-toxic coating will reduce environmental and maintenance costs in Seahawk helicopters. Credit: US Navy

The magnesium alloy used to house the gearbox of Royal Australian Navy SeaHawk helicopters is prone to severe corrosion in marine environments, costing millions of dollars in maintenance every year. To protect the alloy from corrosion, it is covered with a chrome-based coating that is toxic to humans and the environment.

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Crashing helicopters for safety

Mathew Joosten crashes several helicopters a day—without any deaths or injury. He uses computer simulation.

Crashing helicopters can now be done from the safety of the keyboard. Credit: ACSCRC
Crashing helicopters can now be done from the safety of the keyboard. Credit: ACSCRC

A research student of the Cooperative Research Centre for Advanced Composite Structures, Mr Joosten has designed ‘virtual crash test’ software to help accelerate the development of safety systems.

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Parasites betrayed by their genome

Photo: The barber’s pole worm causes deaths and massive production losses in the sheep industry. Credit:Istockphoto Melbourne veterinary researchers are using genomic techniques and bioinformatics to lead them to new specific candidate drugs for the treatment of a devastating parasite known as barber’s pole worm, which causes anaemia, deaths and massive production losses in the sheep industry.

Using the latest gene sequencing technology and the supercomputers of the Victorian Life Sciences Computation Initiative, Prof Robin Gasser’s research group from the University of Melbourne’s Veterinary School have been able to compare barber’s pole worm’s DNA and RNA with that of other organisms in order to track down genes essential to the worm’s growth, development, reproduction and survival. Continue reading Parasites betrayed by their genome

Faster flash flood warnings

Flash flooding, brought on by sudden torrential rain, killed dozens of people in Australia in 2011. Because of their very nature, it has been difficult to provide effective warnings. And that is a significant gap in Australia’s natural disaster management, according to the submission of RMIT University’s Centre for Risk and Community Safety to the 2011 Queensland Floods Commission of Inquiry.

Technology could mean more effective warnings against flash flooding, like the kind that hit Toowoomba, Queensland in January 2011. Credit: KingBob.net
Technology could mean more effective warnings against flash flooding, like the kind that hit Toowoomba, Queensland in January 2011. Credit: KingBob.net

We now have the technology to deliver such warnings, says director of the Centre, Prof John Handmer. “But using it would raise issues about how quickly both the authorities and people at risk are prepared to make critical decisions when they receive the information.”

Continue reading Faster flash flood warnings

Curing cancer with radiation – safely

Prostate and other soft-tissue cancers are often treated with radioactive sources implanted or inserted into the body. But monitoring the dose is problematic.

Curing cancer with radiation – safely
Computer simulation of brachytherapy prostate treatment showing radioactive source trajectories through the pelvic region. Credit: Rick Franich
Medical physicists at Melbourne’s RMIT University are developing a technique to monitor the radiation dose more accurately.

In high dose rate brachytherapy, tumours are targeted by radioactive sources temporarily inserted into the body.

“Until now, it has not been possible to check at the time of delivery whether the doses received by the tumour and by surrounding healthy tissue matched the planned levels,” says Dr Rick Franich, Medical Radiation Physics group leader at the University’s Health Innovations Research Institute.
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Preparing for the worst

Fire fighters should identify what are potentially the worst-case events and prepare for them, even if they are extremely unlikely to occur, says Bushfire Cooperative Research Centre psychology researcher Claire Johnson.

Preparing for the worst
Fire fighters need to be prepared for the worst that can happen. Credit: Queensland Fire and Rescue Service

“A failure to consider worst-case scenario possibilities has been implicated in a number of high-profile investigations into Australian bushfire disasters,” says Claire, who submitted her PhD thesis on worst-case scenario planning to La Trobe University in Melbourne in March this year.

For instance, the inquiries following the Canberra bushfires in 2003 and the Wangary fires on South Australia’s Eyre Peninsula in 2006 both suggested lack of considering the worst contributed to an underestimation of the threat posed.
Continue reading Preparing for the worst

How a molecular assassin operates

The secrets of a molecular assassin could lead to more effective treatments for cancer and viral diseases, better therapy for autoimmune conditions, and a deeper understanding of the body’s defences enabling the development of more tightly focused immunosuppressive drugs.

How a molecular assassin operates
In this simulation, the perforin molecule (blue) punches a hole through the cell membrane (beige) providing access for toxic enzymes (red). Credit: Mike Kuiper
These are just some of the wide-ranging possibilities arising from research which has revealed the structure and function of the protein perforin, a front-line weapon in the body’s fight against rogue cells.

A pivotal role was played by 2006 Science Minister’s Life Scientist of the Year, molecular biologist Prof James Whisstock and his research team at Monash University. It was research fellow Dr Ruby Law who finally worked out how to grow crystals of perforin. And the team was then able to collaborate with Dr Tom Caradoc-Davies of the micro-crystallography beamline at the nearby Australian Synchrotron to reveal its complete molecular structure.
Continue reading How a molecular assassin operates

Saving our skins

Physicist Dr Amanda Barnard has been using supercomputers to find the balance between sun protection and potential toxicity in a new generation of sunscreens which employ nanoparticles.

Dr Amanda Barnard with one of her nanoparticle simulations Credit: L’Oréal/SDP Photo
Dr Amanda Barnard with one of her nanoparticle simulations Credit: L’Oréal/SDP Photo
The metal oxide nanoparticles which block solar radiation are so small they cannot be seen, so the sunscreen appears transparent. But if the particles are too small, they can produce toxic levels of free radicals.

Amanda, who heads CSIRO’s Virtual Nanoscience Laboratory, has been able to come up with a trade-off—the optimum size of particle to provide maximum UV protection for minimal toxicity while maintaining transparency—by modelling the relevant interactions on a supercomputer.
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Seeing fish through rocks

Dr Kate Trinajstic has used synchrotron light and CT scanning to see through rock, in the process discovering how ancient fish developed teeth, jaws and even a womb. Her work is increasing our understanding of how life on Earth evolved.

Seeing fish through rocks
The winner of the 2010 Malcolm McIntosh Prize for Physical Scientist of the Year, Kate Trinajstic. Credit: Ron D’Raine
About 380 million years ago in what is now the Kimberley Ranges in Western Australia, a vast barrier reef formed. In what would have been the inter-reef basins, large numbers of fish were buried relatively intact. Protective limestone balls formed around them and preserved them. When these balls are treated with acetic acid, the main component of vinegar, the surrounding rock dissolves, leaving only fossilised fish bones.

But in the course of studying hundreds of these dissolving balls, Kate began to see what looked like muscle fibres between the bones. She was eventually able to convince her colleagues that irreplaceable soft tissue detail was being lost in the acid treatments.
Continue reading Seeing fish through rocks