To read about Japan-Australia innovation collaborations—including searching for new malaria drugs, giant robot trucks carrying ore, and chewing gum that reverses tooth decay—click here.
Japanese science changing Australia
The impact of Japanese technological prowess on Australian society is obvious for all to see. How we listened to music was transformed by audio recording technologies: from the Walkman to the CD. Home entertainment was changed by video tapes, DVDs, and game consoles. We rely on Japanese innovation in transport—reliable car engineering, the lean manufacturing techniques that made them affordable and, more recently, hybrid cars.
Fundamental science discoveries are bringing a new era of transformation. Japanese researchers were honoured last year with the Nobel Prize for their invention of the blue LED. They succeeded where for 30 years everyone else had failed. Incandescent light bulbs lit the 20th century; the 21st century will be lit by LED lamps—lasting a lifetime and using a fraction of the energy.
In 2006 Shinya Yamanaka discovered how intact mature cells in mice could be reprogrammed to become immature stem cells. By introducing only a few genes, he could reprogram mature cells to become pluripotent stem cells, that is, immature cells that are able to develop into all types of cells in the body. His work is transforming stem cell medicine and many Australian researchers are now using induced pluripotent stem cells to develop stem cell medicines.
The impact of Japanese technological prowess on Australian society is obvious for all to see. How we listened to music was transformed by audio recording technologies: from the Walkman to the CD.
Home entertainment was changed by video tapes, DVDs, and game consoles. We rely on Japanese innovation in transport—reliable car engineering, the lean manufacturing techniques that made them affordable and, more recently, hybrid cars.
Fundamental science discoveries are now bringing a new era of transformation. Japanese researchers were honoured last year with the Nobel Prize for their invention of the blue LED. They succeeded where for 30 years everyone else had failed. Incandescent light bulbs lit the 20th century; the 21st century will be lit by LED lamps— lasting a lifetime and using a fraction of the energy.
In 2006 Shinya Yamanaka discovered how intact mature cells in mice could be reprogrammed to become immature stem cells. By introducing only a few genes, he could reprogram mature cells to become pluripotent stem cells, that is, immature cells that are able to develop into all types of cells in the body. His work is transforming stem cell medicine and many Australian researchers are now using his induced pluripotent stem cells to develop stem cell medicine.
Australian science changing Japan
It’s not a one way trade. Japanese lives are being improved by Australian inventions such as the bionic ear, gum that repairs tooth decay, sleep disorder treatments, lithium to treat bipolar disorder, aircraft black boxes, and anti-flu drugs, which are all in daily use in Japan.
And when you connect to a fast and reliable wi-fi network you can thank Australian astronomers who were searching for black holes and created tools for cleaning up radio waves.
Collaborating for the future
Today there are hundreds of thriving Australia–Japan research collaborations, many of which will have a profound impact on our lives in the years ahead.
Over the past five years, Japan has consistently placed within the 10 countries that have the highest number of collaborations with Australian researchers on Australian Research Council–funded projects. The ARC reports that the most popular disciplines for collaboration with Japan are: material engineering; biochemistry and cell biology; atomic, molecular, nuclear, particle and plasma physics; astronomical and space sciences and plant biology.
Other collaborations
Seeing every cell in a whole adult brain
Scientists from RIKEN, the University of Tokyo, JAST, and the Queensland University of Technology have developed CUBIC—a technique for rapidly imaging the brain. They believe it will be scalable to whole bodies.
Biomedical applications for ‘magic crystals’
CSIRO and Osaka Prefecture University are developing biomedical applications for the massively absorbent metal–organic framework crystals developed by CSIRO.
How our phones track us
Billions of us now have phones that tell us and others where we are and what’s around us. A team from RMIT, Intel, Fudan University and Keio University is exploring the cross-cultural and intergenerational study of this phenomenon, and the implications for privacy, in three key sites: Tokyo, Shanghai and Melbourne.
Scientists are using neutron radiation to look inside solid steel and analyse the stresses within rail tracks. This research will ultimately improve the safety and operational and repair efficiency of heavy-haul railways.
The wheels of heavily laden trains place considerable rolling-contact loading on rail tracks. The heavy loads can change the material properties near the running surface and within the railhead—causing “fatigue”. A number of serious incidents, including derailments, have been attributed to rail failures resulting from rolling-contact fatigue and accumulated residual stress.
Bragg Institute instrument scientist Dr Vladimir Luzin is looking at fatigue in insulated rail joints (IRJs) within a research project initiated by the Cooperative Research Centre for Rail Innovation. IRJs are an integral part of rail track systems, but they are also weak points, and their replacement is the single largest track maintenance cost in New South Wales, apart from ballast work.
“When a rail comes out of a factory it has already some residual stress,” explains Vladimir. “Now we are looking at the atomic level to see how these stresses develop through the life of the rail joints.”
Vladimir uses neutron diffraction to see how residual stresses evolve through different production steps and during service. The beauty of neutrons is that they can penetrate steel—unlike X-rays—and they can be used to map the stresses inside the rail components non-destructively.
Manufacturers and operators want to control and minimise these stresses. This research, backed by modellers and metallurgists, will help industry partners cut costs, modify production methods and develop rails of a quality and strength that can handle increasing loads.
Bragg Institute, Australian Nuclear Science and Technology Organisation, Vladimir Luzin, Tel: +61 2 9717 7262, vladimir.luzin@ansto.gov.au, www.ansto.gov.au
The Bill and Melinda Gates Foundation are supporting the efforts of Queensland University of Technology scientists to design a better banana.
James Dale and a better banana palm for Africa. Credit: QUT
The researchers have already added provitamin A—a compound the body converts to Vitamin A—to the East African Highland banana. Now they are working to boost the iron content of the cooking banana that is a staple food of Uganda.
Led by Prof James Dale, director of University’s Centre for Tropical Crops and Biocommodities, the researchers are working with the Ugandan National Agricultural Research Organisation to modify the bananas genetically to raise their micronutrient levels, and then develop disease-resistant strains to distribute to East African farmers. The research is being funded by a $10-million grant from Bill and Melinda Gates Foundation’s Grand Challenges in Global Health Program.
James and his team developed efficient technology for raising nutrient levels in Cavendish bananas through to field trials in Queensland and then transferred it to Uganda. Ugandan scientists are now using these methods to modify East African Highland bananas genetically to increase their biosynthesis of provitamin A and their accumulation of iron.
Part of the project includes ensuring Ugandans will accept the new fruit, which has deep yellow flesh, thanks to the addition of the Vitamin A precursor, beta-carotene.
The first Australian trials have started of a vaccine to prevent koalas from contracting and spreading the deadly sexually transmitted disease, chlamydia.
Professor Peter Timms is trialling a Chlamydia vaccine for koalas. Credit: QUT
The trials—supervised by Prof Peter Timms and Prof Ken Beagley from Queensland University of Technology (QUT)’s Institute of Health and Biomedical Innovation—have been undertaken safely both in healthy koalas and koalas that already have chlamydial disease. All vaccinated koalas developed a good immune response to the anti-chlamydia vaccine, which shows great promise of making a significant impact on the disease in the near future.
Chlamydia is a major threat to the continued survival of koalas. Almost all populations in Australia are affected by the disease. It is a significant cause of infertility, urinary tract infections, and inflammation in the lining of the eye which often leads to blindness.
Koala numbers are declining across virtually its whole range. In the Koala Coast region of southeast Queensland in 2008 it was estimated that 2332 koalas had been lost in a three-year monitoring period. That represented a 51 per cent decrease.
By studying chlamydial disease in koalas, QUT researchers hope to understand the condition better in general. They believe their work may also hold the key to developing a successful vaccine for use against the human sexually transmitted disease Chlamydia trachomatis, a major cause of infertility in women.
Photo: Professor Peter Timms is trialling a Chlamydia vaccine for koalas.
