Today, 85 per cent of children with leukaemia can be cured, but the outlook for patients over 60 is bleak. Only 10 per cent survive beyond one year as their cancer adapts to weather the storm of standard chemotherapy treatments. Associate Professor Steven Lane wants to change that outlook.
Steven and his team at the QIMR Berghofer Medical Research Institute have developed a method to rapidly profile the genetics of different leukaemia types—of which there are hundreds—and model them in the lab.
Professor Mark Kendall is planning to dispatch the 160-year-old needle and syringe to history. He’s invented a new vaccine technology that’s painless, uses a fraction of the dose, puts the vaccine just under the skin, and doesn’t require a fridge.
The Nanopatch is a 1 cm square piece of silicon with 20,000 microscopic needles engineered on one side. Coat the needles with dry vaccine, push it gently but firmly against the skin, and the vaccine is delivered just under the outer layer of skin.
It’s a technology he invented in response to a call from the Bill and Melinda Gates Foundation seeking ideas for delivery of vaccines in developing countries—where it’s a challenge to keep conventional wet vaccines cold to the point of delivery.
Professor Perry Bartlett is putting people with dementia on treadmills.
He has already reversed dementia and recovered spatial memories in mice through exercise. And in 2016 he and colleagues at The University of Queensland will begin clinical trials to see if exercise will have the same impact in people with dementia. Then he’ll look at depression.
Underpinning these projects is the idea that the brain is constantly changing; and that learning, memory, mood, and many other brain functions are in part regulated by the production of new neurons.
More than 1.2 million Australians have an autoimmune disease. But any two people may experience it very differently, even if their disease has the same name.
Unlike infectious diseases, autoimmune diseases are not passed from person to person. They are our bodies fighting themselves, making every person’s disease unique.
“A lot of clinical trials fail as they treat all patients with a certain ‘disease’ as one big group,” says Professor Carola Vinuesa, from the National Health and Medical Research Council Centre for Research Excellence in Personalised Immunology at The Australian National University.
“Trait-based ecology” enables Macquarie University’s Mark Westoby to explain patterns of species occurrence and abundance and to understand the impacts of climate change and changing patterns of land use. He received the $55,000 NSW Scientist of the Year.
Nanocapsules for drugs delivery: Frank Caruso is making miniature capsules that could better deliver drugs for cancer, AIDS and cardiovascular diseases. He won one of the 2014 Victoria Prizes for Science & Innovation worth $50,000.
Fifty million children in the world’s poorest countries will be vaccinated against the deadly rotavirus by 2015, thanks to the breakthrough work of a quiet Melbourne researcher.
Ruth Bishop’s rotavirus discovery led to the development of the vaccine currently being rolled out by the Global Alliance for Vaccines and Immunisation—and to her declaration as 2013 CSL Florey Medal winner.
Each year, around half a million children die from rotavirus infection and the acute gastroenteritis it causes.
Prof Graeme Clark changed the way we thought about hearing when he gave Rod Saunders the first cochlear implant in 1978—now he might just do it again.
Back then, Graeme brought together a team of engineers and medical personnel; now he’s trying to reveal exactly how the brain is wired for sound—by bringing together software specialists and experts on materials that can interface with the brain.
“We’re aiming to get closer to ‘high fidelity’ hearing for those with a cochlear implant,” says Graeme, now distinguished researcher at NICTA and laureate professor emeritus at the University of Melbourne. “This would mean they could enjoy the subtlety of music or the quiet hum of a dinner party.”