The secrets of a molecular assassin could lead to more effective treatments for cancer and viral diseases, better therapy for autoimmune conditions, and a deeper understanding of the body’s defences enabling the development of more tightly focused immunosuppressive drugs.
In this simulation, the perforin molecule (blue) punches a hole through the cell membrane (beige) providing access for toxic enzymes (red). Credit: Mike KuiperThese are just some of the wide-ranging possibilities arising from research which has revealed the structure and function of the protein perforin, a front-line weapon in the body’s fight against rogue cells.
A pivotal role was played by 2006 Science Minister’s Life Scientist of the Year, molecular biologist Prof James Whisstock and his research team at Monash University. It was research fellow Dr Ruby Law who finally worked out how to grow crystals of perforin. And the team was then able to collaborate with Dr Tom Caradoc-Davies of the micro-crystallography beamline at the nearby Australian Synchrotron to reveal its complete molecular structure. Continue reading How a molecular assassin operates→
New computer models are challenging the conventional wisdom in marine science.
Beth Fulton’s fisheries models are used all over the world. Credit: IstockphotoThese models have revealed for example that: large populations of jellyfish and squid indicate a marine ecosystem in trouble; not all fish populations increase when fishing is reduced—some species actually decline; and, sharks and tuna can use jellyfish as junk food to see them through lean periods.
The models were developed by the 2007 Science Minister’s Life Scientist of the Year, Dr Beth Fulton, a senior research scientist at CSIRO Marine and Atmospheric Research in Hobart. Continue reading Virtual management of the world’s oceans→
Physicist Dr Amanda Barnard has been using supercomputers to find the balance between sun protection and potential toxicity in a new generation of sunscreens which employ nanoparticles.
Dr Amanda Barnard with one of her nanoparticle simulations Credit: L’Oréal/SDP PhotoThe metal oxide nanoparticles which block solar radiation are so small they cannot be seen, so the sunscreen appears transparent. But if the particles are too small, they can produce toxic levels of free radicals.
Amanda, who heads CSIRO’s Virtual Nanoscience Laboratory, has been able to come up with a trade-off—the optimum size of particle to provide maximum UV protection for minimal toxicity while maintaining transparency—by modelling the relevant interactions on a supercomputer. Continue reading Saving our skins→
Dr Benjamin Kile of the Walter and Eliza Hall Institute for Medical Research in Melbourne has found why the blood cells responsible for clotting—platelets—have a short shelf life at the blood bank.
Benjamin Kile, winner of the 2010 Science Minister’s Prize for Life Scientist of the Year. Credit: Bearcage ProductionsThere’s a molecular clock ticking away inside them that triggers their death. He’s also discovered a gene critical for the production of blood stem cells in our bone marrow that happens to be responsible for a range of cancers.
These major discoveries earned Ben the 2010 Science Minister’s Prize for Life Scientist of the Year. Now he is trying to use them to extend the life of blood bank products, and get to the heart of some of the big questions in cancer. Continue reading The life and death of blood cells→
Dr Kate Trinajstic has used synchrotron light and CT scanning to see through rock, in the process discovering how ancient fish developed teeth, jaws and even a womb. Her work is increasing our understanding of how life on Earth evolved.
The winner of the 2010 Malcolm McIntosh Prize for Physical Scientist of the Year, Kate Trinajstic. Credit: Ron D’RaineAbout 380 million years ago in what is now the Kimberley Ranges in Western Australia, a vast barrier reef formed. In what would have been the inter-reef basins, large numbers of fish were buried relatively intact. Protective limestone balls formed around them and preserved them. When these balls are treated with acetic acid, the main component of vinegar, the surrounding rock dissolves, leaving only fossilised fish bones.
But in the course of studying hundreds of these dissolving balls, Kate began to see what looked like muscle fibres between the bones. She was eventually able to convince her colleagues that irreplaceable soft tissue detail was being lost in the acid treatments. Continue reading Seeing fish through rocks→
He’s back in the lab, working to convert the rich supply of stem cells found in the nose into specialised products to repair nerve damage or replace nerve cells lost in disorders such as hearing loss, Alzheimer’s and Parkinson’s disease.
John Shine, winner of the 2010 Prime Minister’s Prize for Science. Credit: Bearcage ProductionsBut that’s just the latest phase in the full and distinguished life of the 2010 winner of Australia’s Prime Minister’s Prize for Science, molecular biologist Prof John Shine.
In 2011, he is stepping down after more than 20 years as executive director of Sydney’s Garvan Institute of Medical Research which, under his guidance, has grown to a staff of more than 500, an annual budget of $50 million, and now boasts significant achievements in cancer, immunology, diabetes and obesity, osteoporosis and neuroscience. Continue reading Back to the future for father of biotechnology→
Cells involved in the first line of our immune defence have been located where they never have been found before—a discovery that could provide insight into diseases like psoriasis and other auto-immune conditions of the skin.
A stain showing the presence of gamma delta T cells (green) in the dermis. The blood vasculature is shown in red, while blue represent collagen. Credit: Centenary Institute
While researchers have known about these cells, called gamma delta T cells in the epidermis or top layer of skin for more than 20 years, this is the first time their presence has been detected in the next layer of skin down, the dermis.
Wolfgang Weninger, who led the study at Sydney’s Centenary Institute, says that gamma delta T cells are of particular interest because they produce a protein thought to be the ‘first responder’ when intruders are detected by the immune system.
Keeping electronics cool in high power applications such as telecommunications and building electronics on the nanoscale are two areas where there is an alternative to traditional silicon—electronics using diamond. Continue reading Diamonds for extreme electronics→
The world’s meat production could be lifted by 10 to 15 per cent if a vaccine can be found to combat the liver fluke.
Juvenile liver fluke parasites which cause serious disease in livestock and humans. Credit: D Piedrafita (Monash); T Spithill (La Trobe).This is the aim of a collaborative bioscience group at the new $288 million Centre for AgriBioscience (AgriBio).
An effective vaccine against liver fluke could not only boost meat production but would also lead to a large reduction in the amount of drugs given to livestock, says Prof Terry Spithill, who is co-director of AgriBio and based at La Trobe University. Continue reading Stopping parasite means more, safer meat→
How do the power plants of the cell—the mitochondria—use their defence mechanisms to fight diseases such as Parkinson’s disease? This debilitating disorder is caused by an accumulation of proteins that have folded incorrectly.
The body’s power plant mitochondria. Credit: Istockphoto.
The misfolded proteins then clump together and form sticky, cell-damaging deposits called plaques.
“We know that mitochondria are at the centre of the aging process,” says Prof Nick Hoogenraad, executive director of the La Trobe Institute for Molecular Science (LIMS). Nick and his team have found a mechanism mitochondria use to remove the plaques that are prone to form as we age.
