Australian scientists elected to Royal Society

Four of Australia’s most accomplished scientists have been elected to the oldest scientific academy in continuous existence, the Royal Society of London.

PROF IAN FRAZER LAUNCHES THE CERVICAL CANCER VACCINE GARDASIL. CREDIT: UNIVERSITY OF QUEENSLAND

Prof Ian Frazer, Prof Alan Cowman, Prof Mark Randolph and Dr Patrick Tam join 40 other scientists to be elected to the Royal Society in 2011, which celebrated its 350th anniversary last year.

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Could we grow drugs using sunflowers?

Queensland researchers believe future cancer drugs could be grown in sunflowers and ultimately delivered as a seed ‘pill’.

PHOTO: DRUGS COULD BE GROWN IN SUNFLOWERS. CREDIT: CDANNA2003
They’re a long way from that outcome. But, as they reported to the XVIII International Botanical Congress in Melbourne earlier this year, they have already shown that sunflowers make a precursor to cancer drugs as part of their defence against insect attack.

The precursor, a small ring-like protein fragment known as SFTI, has already shown potential as a cancer treatment. Until now, however, it has been considered too expensive to produce by conventional means.
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Building a better banana

The Bill and Melinda Gates Foundation are supporting the efforts of Queensland University of Technology scientists to design a better banana.

James Dale and a better banana palm for Africa. Credit: QUT
James Dale and a better banana palm for Africa. Credit: QUT

The researchers have already added provitamin A—a compound the body converts to Vitamin A—to the East African Highland banana. Now they are working to boost the iron content of the cooking banana that is a staple food of Uganda.

Led by Prof James Dale, director of University’s Centre for Tropical Crops and Biocommodities, the researchers are working with the Ugandan National Agricultural Research Organisation to modify the bananas genetically to raise their micronutrient levels, and then develop disease-resistant strains to distribute to East African farmers. The research is being funded by a $10-million grant from Bill and Melinda Gates Foundation’s Grand Challenges in Global Health Program.

James and his team developed efficient technology for raising nutrient levels in Cavendish bananas through to field trials in Queensland and then transferred it to Uganda. Ugandan scientists are now using these methods to modify East African Highland bananas genetically to increase their biosynthesis of provitamin A and their accumulation of iron.

Part of the project includes ensuring Ugandans will accept the new fruit, which has deep yellow flesh, thanks to the addition of the Vitamin A precursor, beta-carotene.

Saving koalas by vaccination

The first Australian trials have started of a vaccine to prevent koalas from contracting and spreading the deadly sexually transmitted disease, chlamydia.

Saving koalas by vaccination
Professor Peter Timms is trialling a Chlamydia vaccine for koalas. Credit: QUT

The trials—supervised by Prof Peter Timms and Prof Ken Beagley from Queensland University of Technology (QUT)’s Institute of Health and Biomedical Innovation—have been undertaken safely both in healthy koalas and koalas that already have chlamydial disease. All vaccinated koalas developed a good immune response to the anti-chlamydia vaccine, which shows great promise of making a significant impact on the disease in the near future.

Chlamydia is a major threat to the continued survival of koalas. Almost all populations in Australia are affected by the disease. It is a significant cause of infertility, urinary tract infections, and inflammation in the lining of the eye which often leads to blindness.

Koala numbers are declining across virtually its whole range. In the Koala Coast region of southeast Queensland in 2008 it was estimated that 2332 koalas had been lost in a three-year monitoring period. That represented a 51 per cent decrease.

By studying chlamydial disease in koalas, QUT researchers hope to understand the condition better in general. They believe their work may also hold the key to developing a successful vaccine for use against the human sexually transmitted disease Chlamydia trachomatis, a major cause of infertility in women.

Photo: Professor Peter Timms is trialling a Chlamydia vaccine for koalas.
Credit: QUT

Institute of Health and Biomedical Innovation, QUT, Peter Timms, Tel: +61 7 3138 6199, p.timms@qut.edu.au; www.ihbi.qut.edu.au/

Is that you in the video?

Is that you in the video?
Clinton Fookes is technical director of QUT’s Airports of the Future. Credit: Queensland University of Technology (QUT).

A Queensland University of Technology (QUT) engineer is developing techniques to automatically identify people in surveillance videos and recognise their movement and behaviour.

The explosion of video surveillance to make public places safer, says Dr Clinton Fookes of the University’s School of Engineering Systems, has created a new challenge for researchers—to make sense of what cameras and computers see. So he is investigating ways to extract and interpret important information from these visual sources.

The data generated by the proliferation of surveillance cameras, as well as the countless images and videos online, he says, are impossible to intelligently use without sophisticated computer vision technology that can automatically extract information from these sources, collate and report on it in real time.

As Clinton’s work is ideally suited to improving security in public places such as airports, one of his roles is technical director of QUT’s Airports of the Future—a major research project aimed at improving the experience of passengers passing through Australia’s airports.

His research in this field could lead to new discoveries in a range of areas including human-computer interaction, security, medical imaging and robotics.

Photo: Clinton Fookes is technical director of QUT’s Airports of the Future.
Credit: QUT

School of Engineering Systems, QUT, Clinton Fookes, Tel: + 61 7 3138 2458, c.fookes@qut.edu.au, staff.qut.edu.au/staff/fookes/

Researcher to fight insects with spider venom

An Australian researcher is working on environmentally friendly insect control methods based on spider venom compounds.

Professor Glenn King recently joined The University of Queensland’s Institute for Molecular Bioscience, where he will further develop his pioneering approach to insecticide discovery.

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Whiplash: who won’t get better?

MRI scan showing fat infiltration into neck muscle. Credit: James Elliot, University of Queensland
MRI scan showing fat infiltration into neck muscle. Credit: James Elliot, University of Queensland

Most people recover from whiplash injuries within the first few months. However, some people have long term pain—lasting months or years. Until now there has been no way of diagnosing these more severe cases.

New research suggests that fat deposits in the neck muscles are the key.

“We’ve found that people with long term injury have large amounts of fat infiltration in their neck muscles,” says Dr James Elliott from the University of Queensland (and former US professional baseball player). “Something is causing that difference, and it isn’t their body weight,” he says.

Algae that make biofuels and hydrogen

IMB_Ben_with_algae An Australian researcher is leading an international team of scientists developing a clean source of energy from microalgae. The team have developed one algae that not only makes oil for biodiesel production but also generates hydrogen. Commercial hydrogen production uses fossil fuels and produces carbon dioxide.

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Tiny particles could assist in breast cancer screening

These optically barcoded nanoparticles could transform cancer diagnosis.
These optically barcoded nanoparticles could transform cancer diagnosis.

Blood tests using nanoparticles carrying molecules which can detect breast cancer biomarkers could save millions of lives and open the way to mass screening for many cancers.

Prof. Matt Trau, of the Australian Institute for Bioengineering & Nanotechnology at the University of Queensland, and his team are using a combination of nanotechnology and molecular biology in the project, funded by a five-year $5 million grant from the National Breast Cancer Foundation.

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L’Oréal Fellow looking for dark energy

Tamara Davis is looking for dark energy. Credit: timothyburgess.net
Tamara Davis is looking for dark energy. Credit: timothyburgess.net

In 1998 astronomers made an astonishing discovery—the expansion of the Universe is accelerating. The discovery required a complete rethink of the standard model used to explain how the Universe works.

“Now we know that stars, planets, galaxies and all that we can see make up just four per cent of the Universe,” says Dr Tamara Davis, a University of Queensland astrophysicist.

“About 23 per cent is dark matter. The balance is thought to be dark energy, which we know very little about.”

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