Intelligent drugs

Dr Georgina Such imagines a miniscule capsule designed like a set of Russian babushka dolls.

Georgina Such is working on smart capsules could change the way we deliver drugs. Credit: L’Oréal Australia/sdpmedia.com.au
Georgina Such is working on smart capsules could change the way we deliver drugs. Credit: L’Oréal Australia/sdpmedia.com.au

The capsule is designed to sneak through the blood stream untouched.

When it finds its target—a cancer cell—it passes into the cell, sheds a layer, finds the part of the cellular machinery it needs to attack, sheds another layer; and then releases its cargo of drugs, destroying the cancer cell and only the cancer cell.

Creating such a capsule may take decades, but Georgina and her colleagues at the University of Melbourne have already developed several materials which have the potential to do the job.

Continue reading Intelligent drugs

Telescope of tiles

No moving parts – a new kind of radio telescope
The Murchison Widefield Array is a telescope with no moving parts. Credit: David Herne, ICRAR

Far outback in Western Australia, 32 tiles—flat, stationary sensors—each carrying 16 dipole antennas have begun collecting scientific data.

These first tiles will ultimately form part of a much bigger array of 512 tiles, the Murchison Widefield Array (MWA)—Australia’s second Square Kilometre Array (SKA) demonstrator project. Like CSIRO’s Australian SKA Pathfinder (ASKAP), the MWA is being built at the remote, radio-quiet Murchison Radio-astronomy Observatory (MRO). Continue reading Telescope of tiles

Nurturing super astronomers at home

SUPER SCIENCE FELLOW DR JAMES ALLISON AT NARRABRI DURING AN OBSERVING RUN AT THE AUSTRALIA TELESCOPE COMPACT ARRAY. CREDIT: ANANT TANNA.
SUPER SCIENCE FELLOW DR JAMES ALLISON AT NARRABRI DURING AN OBSERVING RUN AT THE AUSTRALIA TELESCOPE COMPACT ARRAY. CREDIT: ANANT TANNA.

Advanced telescopes need advanced astronomers to run them. Australia is matching the millions of dollars it is investing in new telescope technology with funds to help train the rising stars of Australian astronomy.

“We’ve had big investments in infrastructure, and now we need young scientists with the expertise to use them,” says Elaine Sadler, professor of Astrophysics at the University of Sydney and chair of the National Committee for Astronomy.

One new tranche of research funding for early career astronomers comes in the form of three-year Super Science Fellowships from the Commonwealth Government. In 2011, 14 young astronomers became Super Science Fellows, joining the 17 who started work in 2010. All up, astronomy will receive one-third of the Federal Government’s $27 million commitment to the Fellowships program. Continue reading Nurturing super astronomers at home

Measuring the Universe from start to finish

THE HUBBLE SPACE TELESCOPE CAN BE USED TO TAKE MEASUREMENTS THAT WILL HELP ANSWER SOME OF THE BIGGEST QUESTIONS ABOUT THE UNIVERSE. CREDIT: NASA/STSCI.
THE HUBBLE SPACE TELESCOPE CAN BE USED TO TAKE MEASUREMENTS THAT WILL HELP ANSWER SOME OF THE BIGGEST QUESTIONS ABOUT THE UNIVERSE. CREDIT: NASA/STSCI.

Scientific puzzles don’t come much bigger than these. How old is the Universe? How big is it? And what is its ultimate fate?

A single number, Hubble’s constant, is the key that can unlock all of those questions, but it’s a number that has proved notoriously hard to accurately measure. Hubble’s constant is the rate at which the Universe is expanding. The first team to accurately make that measurement was co-led by Jeremy Mould, now a professor at Swinburne University of Technology and professorial fellow at the University of Melbourne. Continue reading Measuring the Universe from start to finish

A smarter way to deliver drugs

Georgina Such

Georgina Such, The University of Melbourne (credit: L’Oréal Australia/sdpmedia.com.au)
Georgina Such, The University of Melbourne (credit: L’Oréal Australia/sdpmedia.com.au)

The University of Melbourne

Smart capsules could change the way we deliver drugs.

Today, when we’re treated for cancer, the drug spreads throughout the body indiscriminately. Along the way it causes side-effects such as nausea and hair loss. Continue reading A smarter way to deliver drugs

Parasites betrayed by their genome

Photo: The barber’s pole worm causes deaths and massive production losses in the sheep industry. Credit:Istockphoto Melbourne veterinary researchers are using genomic techniques and bioinformatics to lead them to new specific candidate drugs for the treatment of a devastating parasite known as barber’s pole worm, which causes anaemia, deaths and massive production losses in the sheep industry.

Using the latest gene sequencing technology and the supercomputers of the Victorian Life Sciences Computation Initiative, Prof Robin Gasser’s research group from the University of Melbourne’s Veterinary School have been able to compare barber’s pole worm’s DNA and RNA with that of other organisms in order to track down genes essential to the worm’s growth, development, reproduction and survival. Continue reading Parasites betrayed by their genome

Computing with a single electron

Australian engineers and physicists have developed a ‘single electron reader’, one of the key building blocks needed to make a quantum computer.

Computing with a single electron
Andrew Dzurak (left), Andrea Morello and their colleagues have read the spin of a single electron. Credit: UNSW
Quantum computers will use the spin, or magnetic orientation, of individual electrons for their calculations. And, because of the quantum nature of electrons, quantum computers could be exponentially faster at certain tasks than traditional computers.

In order to employ electron spin, a quantum computer needs both a way of changing the spin state (writing information) and of measuring that change (reading information). Together these two form a quantum bit or qubit – the equivalent of the bit in a conventional computer.
Continue reading Computing with a single electron

Fresh Science 2010

Each year we identify early-career scientists with a discovery and bring them to Melbourne for a communication boot camp. Here are some of their stories.

More at www.freshscience.org.au

Print your own lasers, lights and TV screens

Print your own lasers, lights and TV screens
Jacek Jasieniak sprinkling quantum dots. Credit: Jacek Jasieniak

Imagine printing your own room lighting, lasers, or solar cells from inks you buy at the local newsagent. Jacek Jasieniak and colleagues at CSIRO, the University of Melbourne and the University of Padua in Italy, have developed liquid inks based on quantum dots that can be used to print such devices and in the first demonstration of their technology have produced tiny lasers. Quantum dots are made of semiconductor material grown as nanometre-sized crystals, around a millionth of a millimetre in diameter. The laser colour they produce can be selectively tuned by varying their size.

Cling wrap captures CO2
Colin Scholes operates a test rig for his carbon capture membrane. Credit: CO2 CRC

Cling wrap captures CO2

High tech cling wraps that ‘sieve out’ carbon dioxide from waste gases can help save the world, says Melbourne University chemical engineer, Colin Scholes who developed the technology. The membranes can be fitted to existing chimneys where they capture CO2 for removal and storage. Not only are the new membranes efficient, they are also relatively cheap to produce. They are already being tested on brown coal power stations in Victoria’s La Trobe Valley, Colin says. “We are hoping these membranes will cut emissions from power stations by up to 90 per cent.”

Continue reading Fresh Science 2010

Cementing a greener future

Making cement is the third largest source of carbon emissions in the world after the burning of fossil fuels and deforestation—but the Australian roads of the future could be paved with cement that is made in a process that generates less than half the carbon emissions of traditional methods.

Green cement is now becoming part of Victoria’s roads. Credit: Australian Synchrotron.
Green cement is now becoming part of Victoria’s roads. Credit: Australian Synchrotron.

Each year, the world produces about 12 billion tonnes of concrete and about 1.6 billion tonnes of its key ingredient, Portland cement, which is generated by breaking calcium carbonate into carbon dioxide and calcium oxide.

This produces some 2 billion tons of carbon dioxide—so the Geopolymer and Mineral Processing Group (GMPG) at the University of Melbourne, now led by Dr John Provis, went looking for a lower carbon way of making cement.

They have now developed binders and concretes based on a low-CO2 aluminosilicate compounds called geopolymers.

Continue reading Cementing a greener future

Fighting back against malaria

Rowena Martin

The Australian National University, Canberra/The University of Melbourne

Rowena Martin, The Australian National University, Canberra/The University of Melbourne (credit: L’Oréal Australia/sdpmedia.com.au)
Rowena Martin, The Australian National University, Canberra/The University of Melbourne (credit: L’Oréal Australia/sdpmedia.com.au)

In the 1950s it seemed as if medical science was winning the fight against malaria with the help of the ‘wonder drug’ chloroquine. Over the past half century the drug has saved hundreds of millions of lives.

But now the parasite that causes malaria has fought back. Chloroquine-resistant malaria has become common in developing countries. Rowena Martin is working to understand what happened, and to develop new ways of treating malaria. Continue reading Fighting back against malaria