These major discoveries earned Ben the 2010 Science Minister’s Prize for Life Scientist of the Year. Now he is trying to use them to extend the life of blood bank products, and get to the heart of some of the big questions in cancer.
Continue reading The life and death of blood cells
In 2011, he is stepping down after more than 20 years as executive director of Sydney’s Garvan Institute of Medical Research which, under his guidance, has grown to a staff of more than 500, an annual budget of $50 million, and now boasts significant achievements in cancer, immunology, diabetes and obesity, osteoporosis and neuroscience.
Continue reading Back to the future for father of biotechnology
While researchers have known about these cells, called gamma delta T cells in the epidermis or top layer of skin for more than 20 years, this is the first time their presence has been detected in the next layer of skin down, the dermis.
Wolfgang Weninger, who led the study at Sydney’s Centenary Institute, says that gamma delta T cells are of particular interest because they produce a protein thought to be the ‘first responder’ when intruders are detected by the immune system.
Continue reading Skin deep discovery reveals immune mysteries
Prof Ian Frazer, Prof Alan Cowman, Prof Mark Randolph and Dr Patrick Tam join 40 other scientists to be elected to the Royal Society in 2011, which celebrated its 350th anniversary last year.
Continue reading Australian scientists elected to Royal Society
Mystery still surrounds why women who recover from breast cancer often relapse years later —Dr Marie-Liesse Asselin-Labat is hoping to use her knowledge of breast tissue stem cells to unravel it.In 2006, she was part of the Walter and Eliza Hall Institute team that discovered breast stem cells.
She then built on this finding with a series of studies exploring how these cells develop and are influenced by oestrogen and other steroids.
Her achievements won her a $20,000 L’Oréal Australia For Women in Science Fellowship in 2010. Breast stem cells are critical to normal breast development, but if the breast becomes cancerous they are also likely to be at heart of the problem.
And that’s been the focus of Marie- Liesse’s work. In a series of high impact papers working with mice, she has explored how these breast stem cells develop into the wide range of cells found in a normal breast and how some of them become aggressive cancer cells.
In 2010 she was lead author of a Nature paper revealing that oestrogen and other steroids can control the function of breast stem cells. “It’s via an indirect mechanism important in understanding how stem cells proliferate, and it could lead to new treatments and new drugs,” she says. “But there are basic questions we still need to answer about breast cancer—such as, ‘What is the cell of origin?’ and ‘What causes a cell to go wrong and turn to cancer?’”
Walter and Eliza Hall Institute of Medical Research, Marie-Liesse Asselin-Labat, Tel: +61 3 9345 2495, labat@wehi.edu.au, loreal.scienceinpublic.com.au/marieliesse/
Walter and Eliza Hall Institute of Medical Research
Most women in Australia who have breast cancer recover. But many then relapse years later.
Marie-Liesse Asselin-Labat wants to know why. If she can solve this mystery, her work will open up opportunities for new drugs and treatments. Her achievements to date suggest that she is well placed to succeed.
In 2006 she was part of the Walter and Eliza Hall Institute of Medical Research team that received global attention for its discovery of breast stem cells – a significant step in understanding how breast cancer starts. Marie-Liesse built on this finding with a series of papers exploring how these cells develop and are influenced by oestrogen and other steroids. Continue reading How does breast cancer start?
What if the very thing that assists a fetus to grow in the womb could also prevent disease in a fully grown adult?
Monash Institute of Medical Research scientists have discovered that stem cells from the womb have the potential to treat inflammatory diseases such as lung fibrosis and liver cirrhosis in both children and adults.
Dr Marnie Blewitt wants to know how a human being is made: how does a single fertilised egg develop into an adult with millions of cells performing a myriad of different functions.
“How does a cell know which of its 30,000 or so genes should be active and which should be dormant?” says Marnie, a researcher at the Walter and Eliza Hall Institute of Medical Research.
Blood tests using nanoparticles carrying molecules which can detect breast cancer biomarkers could save millions of lives and open the way to mass screening for many cancers.
Prof. Matt Trau, of the Australian Institute for Bioengineering & Nanotechnology at the University of Queensland, and his team are using a combination of nanotechnology and molecular biology in the project, funded by a five-year $5 million grant from the National Breast Cancer Foundation.
Continue reading Tiny particles could assist in breast cancer screening
Why does influenza make some of us much sicker than others? What are the implications for swine flu (H1N1)? Australian scientists are looking to past outbreaks for the answers.
In July 2009, the Australian Government responded to urgent global calls to use the Southern Hemisphere’s flu season as a catalyst for investigating the severity and global threat of the H1N1 flu strain.