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Could your lab have the next antibiotic?

Could your newly synthesised molecule kill a superbug? Matt Cooper can tell you.

His team is offering a free screening service for the world’s chemists to test their compounds against antibiotic-resistant bacteria, helping them to potentially find a new antibiotic that will fight the rise of these ‘superbugs’.

“We’re helping the community unlock the hidden value of these chemicals,” says Matt, whose team is from the Community for Open Antimicrobial Drug Discovery (CO-ADD), a not-for-profit, global initiative of The University of Queensland’s Institute for Molecular Bioscience. The screening began in February 2015, and Matt has already received thousands of samples from locations including India, Singapore, New Zealand, France, Israel, UK and the USA.

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Insulin in a plant seed

An edible plant seed could deliver your insulin or cancer drugs if David Craik’s research progresses as hoped. His team’s work at The University of Queensland’s Institute for Molecular Bioscience centres on cyclotides, which are a family of exceptionally stable circular proteins that occur naturally in many plants, such as violets and petunia.

Circular proteins naturally occuring in plants such as petunia have inspired David Craik’s research. Credit: The University of Queensland

Inspired by the stability and diversity of natural cyclotides, David’s team has developed a way to join the two ends of a linear protein, allowing them to create ‘designer’ cyclotides that can be incorporated into crop plants, turning them into production factories for therapeutic drugs and insecticides.

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Using neutrons to show weak spots in turbines, railway lines and pipes

From pipes to power station turbines and railway lines, ensuring that engineering components perform under pressure can save lives.

By scattering neutrons from the OPAL research reactor across an object—such as a complex power station turbine—the Australian Nuclear Science and Technology Organisation (ANSTO) can test the integrity and safety of metal components.

Anna Paradowska with Mehdi Soodi (Laser Manager from Hardchrome Engineering) setting up the turbine blade for neutron measurements. Credit: Australian Nuclear Science and Technology Organisation
Anna Paradowska with Mehdi Soodi (Laser Manager from Hardchrome Engineering) setting up the turbine blade for neutron measurements. Credit: Australian Nuclear Science and Technology Organisation

This proactive approach to maintenance is helping to safeguard the power industry from millions of dollars in damage and potential loss of life or injury. For example, ANSTO is helping Hardchrome Engineering test their refurbished turbines and provide a subatomic ‘seal of approval’ for the safety of repairs undertaken.
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