Tag Archives: therapeutic drugs

Fighting stroke damage

A drug based on a molecule naturally present in infants – but which declines in adulthood – can halve the scarring in brains of those who have suffered stroke. And it can be delivered up to a week afterward.

The drug developed by James and Leon minimises the amount of scarring after the wound has been stabilised. Credit: Leon Teo
Enlarged cell bodies (pink), with increased scar-forming (green) following stroke. Credit: Leon Teo

“We hope our work will improve the recovery of the elderly, as well as people in rural and remote communities, who haven’t had access to speedy treatment following a stroke,” says Associate Professor James Bourne at the Australian Regenerative Medicine Institute (ARMI ), and Chief Investigator of the research.
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Insulin in a plant seed

An edible plant seed could deliver your insulin or cancer drugs if David Craik’s research progresses as hoped. His team’s work at The University of Queensland’s Institute for Molecular Bioscience centres on cyclotides, which are a family of exceptionally stable circular proteins that occur naturally in many plants, such as violets and petunia.

Circular proteins naturally occuring in plants such as petunia have inspired David Craik’s research. Credit: The University of Queensland

Inspired by the stability and diversity of natural cyclotides, David’s team has developed a way to join the two ends of a linear protein, allowing them to create ‘designer’ cyclotides that can be incorporated into crop plants, turning them into production factories for therapeutic drugs and insecticides.

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