What began decades ago as the discovery of an antibody from mice that targets human cancer cells is now undergoing human trials in the US as the basis of a treatment for acute leukaemia.
The antibody targets a protein called EphA3, which is found in about half of all acute leukaemias as well as many other human cancers including a significant proportion of malignant melanomas, brain tumours and lung cancers. The antibody, called KB004, has been shown to kill certain types of cancerous tumours grown from human samples.
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