Our blood has a built-in system for breaking up heart attack-inducing clots—and we’re a step closer to drugs that could switch that system on at will.
The molecular structure of plasminogen. Credit: Prof James Whisstock/Australian Synchrotron
Australian researchers have won the decades-long race to define the structure of plasminogen—a protein whose active form quickly dissolves blood clots.
The current crop of clot-busting drugs have many side effects, including bleeding and thinning of the blood, so harnessing the body’s own mechanism for clearing clots could offer a better way. Continue reading Clues to switching off your blood clots→
CSIRO’s Australian Square Kilometre Array Pathfinder (ASKAP) telescope is already booked out for much of its first five years of data gathering, even before it formally begins early operations in 2013.
One of CSIRO’s ASKAP antennas at the MRO. Credit: Barry Turner, CSIRO
More than 400 astronomers from over a dozen nations have already signed up to look for pulsars, measure cosmic magnetic fields, and study millions of galaxies.
ASKAP was built at the specifically radio-quiet Murchison Radio-astronomy Observatory (MRO) in Western Australia as a technology demonstrator for the $2 billion Square Kilometre Array radio telescope. Continue reading Wide open skies for Australian astronomy→
An Australian physicist is unravelling the mystery of how the hot, brilliant stars we see today emerged from our Universe’s “dark age”.
Stuart Wyithe’s models of an early universe will be explored by the next generation of telescope. Credit: Prime Minister’s Science Prizes/Bearcage
Theoretical physicist Prof Stuart Wyithe is one of the world’s leading thinkers on the Universe as it was 13 billion years ago, when there were no stars or galaxies, just cold gas.
In the next few years astronomers will learn much more as powerful new telescopes come online.
Neutrons and native frogs are an unlikely but dynamic duo in the battle against antibiotic-resistant bacteria, commonly known as superbugs, recent research has shown.
The growling grass frog’s skin secretions include disease fighting peptides. Credit: Craig Cleeland
The skin secretions of the Australian green-eyed and growling grass frogs contain peptides (small proteins) that help frogs fight infection. Researchers hope these peptides will offer a new line of defence against a range of human bacterial pathogens, including methicillin-resistant Staphylococcus aureus (MRSA). Continue reading Frog peptides versus superbugs→
Electrodes made of diamond are helping Melbourne researchers build a better bionic eye.
David Garrett’s Melbourne team is designing diamond electrodes to replace light-sensing parts of the retina. Credit: David J. Garrett
Some types of blindness are caused by diseases where the light-sensing part of the retina is damaged, but the nerves that communicate with the brain are still healthy—for example, retinitis pigmentosa and age-related macular degeneration.
Dr David Garrett and his colleagues at the Melbourne Materials Institute at the University of Melbourne are using diamond to build electrodes that can replace the light-sensing function of the retina: they deliver an electrical signal to the eye via a light-sensing camera.
He received the first ever Malcolm McIntosh Prize for Physical Scientist of the Year in 2000, then the Shaw Prize in Astronomy in 2006, the Gruber Cosmology Prize in 2007 and the Nobel Prize for Physics in 2011—it’s been a satisfying progression for Brian Schmidt, professor of astronomy at the Australian National University, and for Australian science. Schmidt led one of two research teams that determined that the expansion of the Universe is accelerating.
Brian Schmidt, the Malcolm McIntosh Physical Scientist of the Year 2000 and 2011 Physics Nobel Laureate. Credit: ANU
But winning awards does not mean he’s resting on his laurels. Apart from countless invitations to speak, Brian has his hands full with commissioning SkyMapper, a new optical telescope equipped with Australia’s largest digital camera at 268 megapixels. And he’s also involved in two significant new facilities pioneering technology to be used in the Square Kilometre Array (SKA), the world’s largest radio telescope: the Murchison Widefield Array and the Australian SKA Pathfinder. And in his spare time, he’s working on one of the next generation of optical telescopes, the Giant Magellan Telescope. Continue reading Prized astronomer continues to contribute→
Prof Graeme Clark changed the way we thought about hearing when he gave Rod Saunders the first cochlear implant in 1978—now he might just do it again.
3-D reconstruction of the left implanted cochlea in the brain of Rod Saunders. Credit: G. Clark; J.C.M. Clark.; M. Clarke; P. Nielsen- NICTA & Dept Otolaryngology, Melbourne University
Back then, Graeme brought together a team of engineers and medical personnel; now he’s trying to reveal exactly how the brain is wired for sound—by bringing together software specialists and experts on materials that can interface with the brain.
“We’re aiming to get closer to ‘high fidelity’ hearing for those with a cochlear implant,” says Graeme, now distinguished researcher at NICTA and laureate professor emeritus at the University of Melbourne. “This would mean they could enjoy the subtlety of music or the quiet hum of a dinner party.”
A new instrument at the Australian Astronomical Observatory (AAO) can sample the light coming from hundreds of galaxies per night—which can tell us new things about the universe.
Astronomer Sam Richards sitting in the prime focus cage at the Anglo-Australian Telescope, where the SAMI instrument usually sits. Credit: Jon Lawrence
Sydney-AAO Multi-object Integral field spectrograph (SAMI) can look at up to 100 galaxies in a night, because it can look at 60 different regions in each of 13 different galaxies, all at once.
Australia’s scientists are among the most productive in the region. That’s the picture that emerges from the Nature Publishing Index 2011 Asia-Pacific released in March 2012
AUSTRALIA RANKS THIRD IN THE ASIA-PACIFIC REGION IN TERMS OF PUBLICATIONS IN NATURE GROUP JOURNALS. CREDIT: NASA VISIBLEEARTH.NASA.GOV
Australia ranks second only to Singapore in terms of science output per capita and per scientist in the Index, which measures the publication of research articles in Nature research journals by Asia-Pacific nations and institutions. Singapore and Australia are also first and second in the Asia-Pacific respectively in terms of GDP per capita. Continue reading Australian science’s place in Asia→
Queensland scientists are helping radiologists to spot the more subtle signs of breast cancer, using computer tools and magnetic resonance imaging (MRI).
Photo: Contrast-enhanced MRI of a breast. Credit: Yaniv Gal
Currently MRI allows radiologists to detect lumps or other growths by creating a 3D anatomical image of the breast.
Prof Stuart Crozier and his team at the University of Queensland have developed a computer tool that improves MRI detection by spotting more subtle indicators of cancer.
“When cancers are just starting to form, they form abnormal blood vessels very early, to feed their rapid cell division,” Stuart says.
“By seeing how certain contrast agents move through the tissue, we can pick up the formation of these blood vessels.”
Photo: Research Assistant Michael Wildermoth works with the software that shows how certain contrast agents move through breast tissue. Credit: Kim Nunes
This works towards solving two issues with conventional MRIs.
First, it should reduce the number of false positive results and therefore the number of women put through biopsies of benign tumours.
Second, this should catch tumours earlier, not just when tumours are big enough to discern visually.
“The goal is to assist radiologists to identify areas of cancer risk that may not be obvious on conventional images,” Stuart says.
Stuart, a Fellow of the Australian Academy for Technological Sciences and Engineering (ATSE), was recently presented with a 2012 Clunies Ross Award for his contributions to the engineering of magnetic resonance imaging (MRI) technology.
The research, funded as an Australian Research Council’s Discovery Project, is now undergoing trials with 140 women at private radiology firm Queensland X-ray.
Photo: Contrast-enhanced MRI of a breast.
Credit: Yaniv Gal
Photo: Research Assistant Michael Wildermoth works with the software that shows how certain contrast agents move through breast tissue.
Credit: Kim Nunes
