Better vaccines are needed for the global fight against tuberculosis (TB) with nine million new cases annually. Indonesia had more than 320,000 reported cases in 2014, while Australia’s reported cases were just over 1,000. But the rise of drug-resistant TB poses a threat to all countries.
Two proteins from the tuberculosis bacterium have shown promising results in investigations for a new vaccine in mice. Scientists from Universitas Gadjah Mada (UGM) in Yogyakarta, with colleagues from the Centenary Institute and the University of Sydney in Australia, have found that the injected proteins can prime the immune system to induce protection against TB in mice.
Better vaccines are needed for the global fight against tuberculosis (TB). The Global Fund reports an estimated nine million new cases globally per year of TB, which is second only to AIDS as the world’s most deadly infectious disease.
Indonesia had more than 320,000 reported cases in 2014 according to the World Health Organization, while Australia’s reported cases were just over 1,000. But the rise of drug-resistant TB poses a threat to all countries.
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Cells involved in the first line of our immune defence have been located where they never have been found before—a discovery that could provide insight into diseases like psoriasis and other auto-immune conditions of the skin.
While researchers have known about these cells, called gamma delta T cells in the epidermis or top layer of skin for more than 20 years, this is the first time their presence has been detected in the next layer of skin down, the dermis.
Wolfgang Weninger, who led the study at Sydney’s Centenary Institute, says that gamma delta T cells are of particular interest because they produce a protein thought to be the ‘first responder’ when intruders are detected by the immune system.