Tag Archives: skin cancer

Expanding treatments for the ‘Australian’ cancer

The chances of surviving melanoma are getting better every year. But some cancers still become ‘resistant’ to treatment, and others don’t respond at all.

Helen and her colleagues are searching for clues on how people will respond to treatment. Credit: Carolyn Seri for Melanoma Institute Australia Report
Helen and her colleagues are searching for clues on how people will respond to treatment. Credit: Carolyn Seri for Melanoma Institute Australia Report

A collection of over 10,000 blood and 4,900 tissue samples from the biobank at the Melanoma Institute Australia is being used to hunt for clues to predict which patients won’t be responsive to treatment from day one. The researchers, from Macquarie University, are also looking for the basis of developed resistance by the cancer.

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Saving our skins

Physicist Dr Amanda Barnard has been using supercomputers to find the balance between sun protection and potential toxicity in a new generation of sunscreens which employ nanoparticles.

Dr Amanda Barnard with one of her nanoparticle simulations Credit: L’Oréal/SDP Photo
Dr Amanda Barnard with one of her nanoparticle simulations Credit: L’Oréal/SDP Photo
The metal oxide nanoparticles which block solar radiation are so small they cannot be seen, so the sunscreen appears transparent. But if the particles are too small, they can produce toxic levels of free radicals.

Amanda, who heads CSIRO’s Virtual Nanoscience Laboratory, has been able to come up with a trade-off—the optimum size of particle to provide maximum UV protection for minimal toxicity while maintaining transparency—by modelling the relevant interactions on a supercomputer.
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Unmasking melanoma early

There’s a new diagnostic tool being developed to target melanoma, the deadly form of skin cancer with which more than 10,000 Australians are diagnosed each year.

Unmasking melanoma early
The red arrows show a melanoma tumour. The PET/CT scan on the right shows how the MEL050 tracer highlights the location, size and spread of melanoma. Credit: Peter MacCallum Cancer Centre
It’s a chemical compound designed to highlight small traces of these cancer cells in the body.

Melanoma occurs when the cells that make melanin, the dark pigment normally found in the skin, become cancerous. Melanoma cells often spread elsewhere in the body before the primary tumours are detected and removed surgically. Clusters of these melanoma cells can be hard to detect before they grow into tumours by which time they are often incurable.
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