Only 10 per cent of prostate cancers are lethal, but which ones? Australian researchers have tracked the mutations that drive the cancer to spread through the body, and eventually become lethal.
Bioinformaticians can use Circos plots to visualise how cancer genomes differ from healthy ones. Credit: Peter Casamento
The research shows they can be detected in the original tumour and even in blood samples. Testing the DNA of prostate cancer cells may help clinicians in the future identify which cancers need to be urgently removed and which ones might simply be monitored.
“Some advanced cancer cells evolve the ability to break away from their original location, travel through the bloodstream and create secondary tumours in another part of the body,” explains Clare Sloggett, Bioinformatician and Research Fellow at the Victorian Life Sciences Computation Initiative (VLSCI). “Cells in this state of metastasis are the most deadly.”
Prostate cancers are made up of hungry, growing cells. Now we’ve discovered how to cut off their food supply thanks to a study published in Cancer Research and supported by Movember. More below. Also Australian science discoveries you may have missed from the past week. Heart cells growing in a test-tube – Melbourne How birds […]
Prostate and other soft-tissue cancers are often treated with radioactive sources implanted or inserted into the body. But monitoring the dose is problematic.
Computer simulation of brachytherapy prostate treatment showing radioactive source trajectories through the pelvic region. Credit: Rick FranichMedical physicists at Melbourne’s RMIT University are developing a technique to monitor the radiation dose more accurately.
In high dose rate brachytherapy, tumours are targeted by radioactive sources temporarily inserted into the body.
“Until now, it has not been possible to check at the time of delivery whether the doses received by the tumour and by surrounding healthy tissue matched the planned levels,” says Dr Rick Franich, Medical Radiation Physics group leader at the University’s Health Innovations Research Institute. Continue reading Curing cancer with radiation – safely→
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