Fighting disease together

Malaria kills 500,000 people every year. And 90 per cent of those are children. Griffith University researchers are screening hundreds of thousands of compounds supplied by Japanese companies to find the right compound with activity against the malaria parasite.

Japan’s Global Health Innovative Technology Fund is supporting the research as part of their search for new ways to fight malaria.

“GHIT is a fund that invests in partnerships between Japanese and non-Japanese entities,” says BT Slingsby, the Executive Director of GHIT.

“Many of those entities are in Australia including The University of Melbourne, The Walter and Eliza Hall Institute, and Griffith University.”

“Currently we’re working with companies such as Daiichi-Sankyo, Takeda, Mitsubishi Tanabe, and Eisai,” says Griffith University’s Vicky Avery. 

They bring those compounds to us. We then dispense them into plates which contain the parasite we’re trying to kill.  After they’ve been incubated for a period of time we then look to see whether they’ve had an effect in killing the parasites.

“Once one defines a hit, usually it’s the pharmaceutical company that drives forward the further development of that compound to create a drug.

“This collaboration is fantastic in that it has three groups who complement each other,” Vicky says.

The Japanese pharma companies bring expertise in drug discovery and development.  GHIT has managed to pull together significant funding from both global partners as well as the Japanese Government. And Griffith University brings the biology expertise.

Are memories stored in DNA?

The idea that long-term memory might be stored in our brain’s DNA is being tested by Professor Geoff Faulkner, using brains affected by Alzheimer’s.

Geoff has already shown that the DNA in our brains is different to the DNA in the rest of our bodies and that it changes as we learn. He’s proposing that these changes are associated with how we store our long-term memories.

More recently, he’s linked these differences to the function of genes in the hippocampus, the part of the brain that controls memory and spatial navigation, and has been implicated in memory loss with ageing, schizophrenia and Alzheimer’s disease. Continue reading Are memories stored in DNA?

Improving survival for patients with acute leukaemia

Today, 85 per cent of children with leukaemia can be cured, but the outlook for patients over 60 is bleak. Only 10 per cent survive beyond one year as their cancer adapts to weather the storm of standard chemotherapy treatments. Associate Professor Steven Lane wants to change that outlook.

Steven and his team at the QIMR Berghofer Medical Research Institute have developed a method to rapidly profile the genetics of different leukaemia types—of which there are hundreds—and model them in the lab.

This allows them to work with many leukaemia types simultaneously, providing a cheaper, faster and more accurate model of the leukaemia. Continue reading Improving survival for patients with acute leukaemia

Cars, planes…partners in advanced manufacturing

Australian and American researchers and businesses are partnering to bring new manufacturing technologies to market

Paint fit for a Dreamliner

Next time you board a new Boeing Dreamliner, take note of its Australian paint.

Developed by researchers at CSIRO, Australia’s national science agency, ‘Paintbond’ has now been adopted across the entire Boeing aircraft fleet, and more than 1,000 aircraft have been re-coated using the technology so far.

Why is it better? The new spray-on topcoat paint technology saves time, reduces the impact on the environment, and is safer to use.

Continue reading Cars, planes…partners in advanced manufacturing

From the ocean floor to batteries—partners in energy

Heading into deep water

Perth researchers help Chevron keep oil and gas flowing smoothly

Out in the Gulf of Mexico Chevron are operating a $7.5 billion platform that’s recovering oil and gas from two-kilometre-deep ocean.

It’s the largest and deepest operation in the Gulf, with over 146km of pipeline bringing oil and gas to refineries.

But pipelines operating at extreme depths in cold water and crushing pressure are prone to blockage. University of Western Australia researchers are helping Chevron keep oil and gas flowing through deep-water pipes.

Continue reading From the ocean floor to batteries—partners in energy

Keeping in shape: what happens to red blood cells in storage?

Understanding why red blood cells get out of shape during storage could help improve the effectiveness and safety of blood transfusions.

So, Marie-Anne Balanant and Sarah Barns are combining biological and engineering expertise, to create a model of how different parts of ageing red blood cell membranes react when a force is applied.

They hope to propose strategies to improve blood storage practices and create better transfusion outcomes for patients. 

Continue reading Keeping in shape: what happens to red blood cells in storage?

Measuring the risk of an Australian Zika outbreak

The conditions have been right for Zika virus to spread during the warmer months of past years in Townsville, Cairns and Rockhampton, according to research led by the Australian Red Cross Blood Service.

Using temperature data from January 2015 to December 2016, the team modelled the ability of mosquitoes to spread the virus in four Queensland cities. Brisbane (the fourth city) was the only site where the risk was low.  

“If locations experience outbreaks of dengue, the conditions would also be right for outbreaks of Zika,” says lead researcher Dr Elvina Viennet.

The findings emphasise the need for imported cases to be reported immediately, Elvina says.

Continue reading Measuring the risk of an Australian Zika outbreak

Saving seagrass sanctuaries

Seagrass meadows provide food and habitat for everything from dugongs and birds to fish and tiny crabs.

Using maths to protect seagrass meadows and the communities they support .
Using maths to protect seagrass meadows and the communities they support .

Globally we’re losing over 100 sq. km per year due to dredging, coastal developments and runoff. That’s bad news for the animals they support, and bad news for us too, as seagrass supports healthy coastal fisheries as well as acting as a carbon store.

To see how seagrass can be given a fighting chance, Dr Paul Wu at the ARC Centre of Excellence for Mathematical and Statistical Frontiers and collaborators have put an extended modelling technique to new use, predicting seagrass health and suggests how some modified human activities could reduce the damage.

Continue reading Saving seagrass sanctuaries

Can algae fuel our future?

We can make biofuels with algae, but can we make them commercially viable?

A University of Queensland (UQ) research team is working towards it – and Siemens, Neste Oil Corp, the Queensland Government and others have joined their quest.

The Solar Biofuels Research Centre is one of the most advanced national facilities investigating the development and use of high-efficiency microalgae production platforms.

Continue reading Can algae fuel our future?

The ageing brain can repair itself

Professor Perry Bartlett is putting people with dementia on treadmills.

Mapping the vast networks of the brain; 10,000 million neurons, each with 10,000 connections. Credit: Queensland Brain Institute
Mapping the vast networks of the brain; 10,000 million neurons, each with 10,000 connections. Credit: Queensland Brain Institute

He has already reversed dementia and recovered spatial memories in mice through exercise. And in 2016 he and colleagues at The University of Queensland will begin clinical trials to see if exercise will have the same impact in people with dementia. Then he’ll look at depression.

Underpinning these projects is the idea that the brain is constantly changing; and that learning, memory, mood, and many other brain functions are in part regulated by the production of new neurons.

Continue reading The ageing brain can repair itself